Publication	Data		Fish	Anatomy
Khrystoforova et al., 2022	Figure 1		lrp5biu102/biu102 (AB)	caudal fin Ab1-lrp5 labeling absent, abnormal whole organism decreased life span, abnormal whole organism viability, abnormal
	Figure 2		lrp5biu102/biu102 (AB)	cranial vault bone mineralization decreased process quality, abnormal cranial vault decreased mass density, abnormal head deformed, abnormal opercle bone mineralization decreased process quality, abnormal skeletal tissue decreased mass density, abnormal ventral mandibular arch bone mineralization decreased process quality, abnormal vertebral column curved, abnormal vertebral column kinked, abnormal
	Figure 3		lrp5biu102/biu102 (AB)	nasal bone increased angle to mouth, abnormal parasphenoid decreased length, abnormal parasphenoid malformed, abnormal
	Figure 5		lrp5biu102/biu102 (AB)	cranium acp5a expression increased amount, abnormal cranium map3k5 expression increased amount, abnormal cranium mef2d expression increased amount, abnormal cranium mmp13a.1 expression increased amount, abnormal cranium mmp9 expression increased amount, abnormal
	Figure 6		lrp5biu102/biu102 (AB)	lepidotrichium proximal side bifurcated, abnormal scale bone mineralization decreased process quality, abnormal scale osteoclast active, abnormal
Bek et al., 2021	Fig. 1		lrp5sa11097/+ (AB) ,   AB + CRISPR3-lrp5 ,   lrp5sa11097/sa11097 (AB)	caudal fin Ab1-lrp5 labeling absent, abnormal caudal fin Ab1-lrp5 labeling decreased amount, abnormal
	Fig. 2		AB + CRISPR3-lrp5 ,   lrp5sa11097/sa11097 (AB)	ceratobranchial cartilage decreased length, abnormal ceratobranchial cartilage increased angle to ceratobranchial cartilage, abnormal ceratohyal cartilage decreased length, abnormal ceratohyal cartilage increased angle to ceratohyal cartilage, abnormal head decreased length, abnormal Meckel's cartilage decreased length, abnormal
	Fig. 3		AB + CRISPR3-lrp5 ,   lrp5sa11097/sa11097 (AB)	notochord bone mineralization decreased process quality, abnormal
	Fig. 4		AB + CRISPR3-lrp5 ,   lrp5sa11097/sa11097 (AB)	bone tissue calcium cation decreased amount, abnormal bone tissue magnesium cation decreased amount, abnormal bone tissue phosphate decreased amount, abnormal centrum decreased mass density, abnormal centrum decreased thickness, abnormal centrum decreased volume, abnormal ceratohyal bone increased angle to ceratohyal bone, abnormal head decreased length, abnormal
Takita et al., 2020	Fig. 3		lrp5sa11097/sa11097	eye prom1a expression decreased amount, abnormal eye prom1b expression decreased amount, abnormal eye rbp1.2 expression decreased amount, abnormal
Xia et al., 2017	Fig. 3		WT + MO5-lrp5 + MO6-lrp5 ,   s356tTg + MO5-lrp5 + MO6-lrp5	inner ear morphology, abnormal neuromast decreased size, abnormal neuromast hair cell decreased amount, abnormal neuromast hair cell stereocilium decreased amount, abnormal neuromast hair cell stereocilium decreased length, abnormal neuromast hair cell stereocilium decreased thickness, abnormal neuromast support cell decreased amount, abnormal otic vesicle decreased size, abnormal otolith absent, abnormal otolith decreased amount, abnormal posterior lateral line neuromast decreased amount, abnormal
	Fig. 4		WT + MO5-lrp5 + MO6-lrp5	sensory perception of sound disrupted, abnormal startle response process quality, abnormal swimming behavior process quality, abnormal
	Fig. 5		WT + MO5-lrp5 + MO6-lrp5	otic vesicle cell population proliferation decreased occurrence, abnormal whole organism axin2 expression decreased amount, abnormal whole organism lef1 expression decreased amount, abnormal whole organism myca expression decreased amount, abnormal whole organism sox2 expression decreased amount, abnormal
Willems et al., 2015	Fig. 2		WT + MO3-lrp5 + MO4-lrp5 ,   WT + MO3-lrp5 + MO4-lrp5 + MO4-tp53	ceratobranchial 1 cartilage aplastic, abnormal ceratobranchial 2 cartilage aplastic, abnormal ceratobranchial 3 cartilage aplastic, abnormal ceratobranchial 4 cartilage aplastic, abnormal cranium lacks parts or has fewer parts of type ceratobranchial cartilage, abnormal cranium malformed, abnormal embryonic cranial skeleton morphogenesis process quality, abnormal fourth ventricle swollen, abnormal
	Fig. 3		WT + MO3-lrp5 + MO4-lrp5 ,   w25Tg + MO3-lrp5 + MO4-lrp5	cranial neural crest cell lef1 expression decreased distribution, abnormal cranial neural crest cell canonical Wnt signaling pathway decreased process quality, abnormal hindbrain canonical Wnt signaling pathway decreased process quality, abnormal hindbrain GFP expression decreased distribution, abnormal midbrain hindbrain boundary GFP expression decreased distribution, abnormal tail bud GFP expression decreased distribution, abnormal
	Fig. 4		WT + MO3-lrp5 + MO4-lrp5 ,   ba2Tg + MO3-lrp5 + MO4-lrp5	cranial neural crest cell crestin expression decreased distribution, abnormal cranial neural crest cell dlx2a expression decreased distribution, abnormal cranial neural crest cell decreased amount, abnormal cranial neural crest cell EGFP expression decreased distribution, abnormal cranial neural crest cell mislocalised, abnormal cranial neural crest cell neural crest cell migration decreased process quality, abnormal rhombomere 6 crestin expression mislocalised, abnormal rhombomere 6 dlx2a expression mislocalised, abnormal rhombomere 6 EGFP expression mislocalised, abnormal
	Fig. 5		WT + CRISPR2-lrp5 ,   WT + CRISPR1-lrp5 + CRISPR2-lrp5 ,   WT + CRISPR1-lrp5	ceratobranchial 1 cartilage aplastic, abnormal ceratobranchial 2 cartilage aplastic, abnormal ceratobranchial 3 cartilage aplastic, abnormal ceratobranchial 4 cartilage aplastic, abnormal ceratohyal cartilage orientation ceratohyal cartilage, abnormal cranial neural crest cell crestin expression decreased distribution, abnormal cranial neural crest cell neural crest cell migration decreased process quality, abnormal embryonic viscerocranium morphogenesis process quality, abnormal hindbrain dorsal region crestin expression mislocalised, abnormal
	Fig. 6		WT + MO3-lrp5 + MO4-lrp5	cell proliferation in hindbrain decreased occurrence, abnormal hindbrain ccnd1 expression increased distribution, abnormal
	Fig. 7		y1Tg + MO3-lrp5 + MO4-lrp5	ceratobranchial 1 cartilage hypoplastic, abnormal ceratobranchial 2 cartilage aplastic, abnormal ceratobranchial 3 cartilage aplastic, abnormal ceratobranchial 4 cartilage aplastic, abnormal cranium malformed, abnormal embryonic viscerocranium morphogenesis process quality, abnormal
Lu et al., 2013	Fig. 7		as3Tg + MO1-lrp5	liver decreased size, abnormal
Chen et al., 2009	Fig. 4		WT + MO1-lrp5	brain morphology, abnormal convergent extension involved in neural plate elongation disrupted, abnormal