TALEN

TALEN1-spx

ID

ZDB-TALEN-180406-1

Name

TALEN1-spx

Previous Names

None

Target

spx (1)

Target Sequence 1

5' - TTGTGTCCCATTCCT - 3'

Target Sequence 2

5' - AACATTGCATGACATT - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 4

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
zf2090	spx

Expression

Gene expression in Wild Types + TALEN1-spx

No data available

Phenotype

Phenotype resulting from TALEN1-spx

No data available

Phenotype of all Fish created by or utilizing TALEN1-spx

Phenotype	Fish	Conditions	Figures
hypothalamus cart1 expression increased amount, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 4 from Zheng et al., 2017
blood plasma triglyceride increased amount, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 6 from Zheng et al., 2017
blood plasma glucose increased amount, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 6 from Zheng et al., 2017
regulation of appetite decreased process quality, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 3 from Zheng et al., 2017
hypothalamus npy expression decreased amount, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 4 from Zheng et al., 2017
hypothalamus pomca expression increased amount, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 4 from Zheng et al., 2017
blood plasma high-density lipoprotein cholesterol increased amount, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 6 from Zheng et al., 2017
blood plasma cholesterol increased amount, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 6 from Zheng et al., 2017
ovary spx expression absent, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. s2 from Zheng et al., 2017
hypothalamus agrp expression increased amount, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 4 from Zheng et al., 2017
eating behavior increased occurrence, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 3 from Zheng et al., 2017
blood plasma protein increased amount, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 6 from Zheng et al., 2017
nucleus of the medial longitudinal fasciculus synencephalon spx expression absent, abnormal	spx^{zf2090/zf2090} (AB)	standard conditions	Fig. 1 from Zheng et al., 2017

Citations

Include unpublished citations

Zheng, B., Li, S., Liu, Y., Li, Y., Chen, H., Tang, H., Liu, X., Lin, H., Zhang, Y., Cheng, C.H.K. (2017) Spexin Suppress Food Intake in Zebrafish: Evidence from Gene Knockout Study. Scientific Reports. 7:14643

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