Morpholino

MO2-scn1lab

ID
ZDB-MRPHLNO-150720-3
Name
MO2-scn1lab
Previous Names
None
Target
Sequence
5' - CTGAGCAGCCATATTGACATCCTGC - 3'
ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Disclaimer
Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.
Note
Translation-blocking MO.
Genome Resources
None
Target Location
Genomic Features
No data available
Expression
Gene expression in Wild Types + MO2-scn1lab
No data available
Phenotype
Phenotype resulting from MO2-scn1lab
Phenotype Fish Figures
brain functionality, abnormal AB + MO2-scn1lab Fig. 3 with image from Zhang et al., 2015
brain glutamatergic neuron GFP expression increased amount, abnormal nns14Tg; nns25Tg + MO2-scn1lab Figure 3 with image from Brenet et al., 2019
brain glutamatergic neuron increased ratio brain GABAergic neuron, abnormal nns14Tg; nns25Tg + MO2-scn1lab Figure 3 with image from Brenet et al., 2019
brain microglial cell GFP expression increased amount, abnormal gl23Tg/gl23Tg + MO2-scn1lab Figure 3 with image from Brenet et al., 2024
brain microglial cell mCherry expression spatial pattern, abnormal gl23Tg/gl23Tg + MO2-scn1lab Figure 1 with image from Brenet et al., 2024
brain neuron decreased amount, abnormal nns14Tg; nns25Tg + MO2-scn1lab Figure 3 with image from Brenet et al., 2019
brain postsynapse Ab7-gphn labeling decreased distribution, abnormal WT + MO2-scn1lab Figure 2 with image from Brenet et al., 2019
brain postsynapse ab1-dlg4 labeling increased distribution, abnormal WT + MO2-scn1lab Figure 2 with image from Brenet et al., 2019
calcium-mediated signaling increased occurrence, abnormal zf498Tg + MO2-scn1lab Figure 1 with image from Brenet et al., 2019
glutamatergic neuron apoptotic process increased occurrence, abnormal nns14Tg; nns25Tg + MO2-scn1lab Figure 4 with image from Brenet et al., 2019
locomotion increased occurrence, abnormal AB + MO2-scn1lab Fig. 1 with image from Zhang et al., 2015
locomotory behavior process quality, abnormal AB + MO2-scn1lab Fig. S1,  Fig. S2 from Zhang et al., 2015
microglial cell interleukin-1 beta production increased occurrence, abnormal gl23Tg/gl23Tg; zf4329Tg/zf4329Tg + MO2-scn1lab Figure 3 with image from Brenet et al., 2024
microglial cell locomotory behavior decreased rate, abnormal gl23Tg/gl23Tg + MO2-scn1lab Figure 2 with image from Brenet et al., 2024
microglial cell regulation of cell shape decreased process quality, abnormal gl23Tg/gl23Tg + MO2-scn1lab Figure 1 with image from Brenet et al., 2024
neuron apoptotic, abnormal nns14Tg; nns25Tg + MO2-scn1lab Figure 4 with image from Brenet et al., 2019
neuronal signal transduction amplitude, abnormal zf498Tg + MO2-scn1lab Figure 1 with image from Brenet et al., 2019
neuronal signal transduction increased occurrence, abnormal zf498Tg + MO2-scn1lab Figure 1 with image from Brenet et al., 2019
optic tectum calcium ion transmembrane transport increased frequency, abnormal zf498Tg/zf498Tg + MO2-scn1lab Figure 4 with image from Brenet et al., 2024
optic tectum neuronal action potential increased frequency, abnormal zf498Tg/zf498Tg + MO2-scn1lab Figure 4 with image from Brenet et al., 2024
swim bladder uninflated, abnormal AB + MO2-scn1lab Fig. 1 with image from Zhang et al., 2015
swimming behavior increased duration, abnormal WT + MO2-scn1lab Figure 5 with image from Brenet et al., 2024
whole organism increased behavioural activity, abnormal AB + MO2-scn1lab Fig. S1 from Zhang et al., 2015
whole organism increased pigmentation, abnormal AB + MO2-scn1lab Fig. 1 with image from Zhang et al., 2015
whole organism anatomical axis curved, abnormal AB + MO2-scn1lab Fig. 1 with image from Zhang et al., 2015
Phenotype of all Fish created by or utilizing MO2-scn1lab
Phenotype Fish Conditions Figures
brain microglial cell GFP expression increased amount, abnormal gl23Tg/gl23Tg + MO2-scn1lab standard conditions Figure 3 with image from Brenet et al., 2024
microglial cell regulation of cell shape decreased process quality, abnormal gl23Tg/gl23Tg + MO2-scn1lab standard conditions Figure 1 with image from Brenet et al., 2024
brain microglial cell mCherry expression spatial pattern, abnormal gl23Tg/gl23Tg + MO2-scn1lab standard conditions Figure 1 with image from Brenet et al., 2024
microglial cell locomotory behavior decreased rate, abnormal gl23Tg/gl23Tg + MO2-scn1lab standard conditions Figure 2 with image from Brenet et al., 2024
optic tectum calcium ion transmembrane transport increased frequency, abnormal zf498Tg/zf498Tg + MO2-scn1lab standard conditions Figure 4 with image from Brenet et al., 2024
optic tectum neuronal action potential increased frequency, abnormal zf498Tg/zf498Tg + MO2-scn1lab standard conditions Figure 4 with image from Brenet et al., 2024
whole organism anatomical axis curved, abnormal AB + MO2-scn1lab standard conditions Fig. 1 with image from Zhang et al., 2015
whole organism increased behavioural activity, abnormal AB + MO2-scn1lab standard conditions Fig. S1 from Zhang et al., 2015
brain functionality, abnormal AB + MO2-scn1lab standard conditions Fig. 3 with image from Zhang et al., 2015
swim bladder uninflated, abnormal AB + MO2-scn1lab standard conditions Fig. 1 with image from Zhang et al., 2015
thigmotaxis disrupted, abnormal AB + MO2-scn1lab heat shock Fig. 5 with image from Zhang et al., 2015
locomotory behavior process quality, abnormal AB + MO2-scn1lab standard conditions Fig. S1,  Fig. S2 from Zhang et al., 2015
whole organism increased pigmentation, abnormal AB + MO2-scn1lab standard conditions Fig. 1 with image from Zhang et al., 2015
locomotion increased occurrence, abnormal AB + MO2-scn1lab standard conditions Fig. 1 with image from Zhang et al., 2015
neuromuscular process controlling posture disrupted, abnormal AB + MO2-scn1lab heat shock Fig. 5 with image from Zhang et al., 2015
brain postsynapse Ab7-gphn labeling decreased distribution, abnormal WT + MO2-scn1lab standard conditions Figure 2 with image from Brenet et al., 2019
swimming behavior increased duration, abnormal WT + MO2-scn1lab standard conditions Figure 5 with image from Brenet et al., 2024
brain postsynapse ab1-dlg4 labeling increased distribution, abnormal WT + MO2-scn1lab standard conditions Figure 2 with image from Brenet et al., 2019
neuronal signal transduction increased occurrence, abnormal zf498Tg + MO2-scn1lab standard conditions Figure 1 with image from Brenet et al., 2019
neuronal signal transduction amplitude, abnormal zf498Tg + MO2-scn1lab standard conditions Figure 1 with image from Brenet et al., 2019
calcium-mediated signaling increased occurrence, abnormal zf498Tg + MO2-scn1lab standard conditions Figure 1 with image from Brenet et al., 2019
microglial cell interleukin-1 beta production increased occurrence, abnormal gl23Tg/gl23Tg; zf4329Tg/zf4329Tg + MO2-scn1lab standard conditions Figure 3 with image from Brenet et al., 2024
brain glutamatergic neuron increased ratio brain GABAergic neuron, abnormal nns14Tg; nns25Tg + MO2-scn1lab standard conditions Figure 3 with image from Brenet et al., 2019
brain glutamatergic neuron GFP expression increased amount, abnormal nns14Tg; nns25Tg + MO2-scn1lab standard conditions Figure 3 with image from Brenet et al., 2019
brain neuron decreased amount, abnormal nns14Tg; nns25Tg + MO2-scn1lab standard conditions Figure 3 with image from Brenet et al., 2019
glutamatergic neuron apoptotic process increased occurrence, abnormal nns14Tg; nns25Tg + MO2-scn1lab standard conditions Figure 4 with image from Brenet et al., 2019
neuron apoptotic, abnormal nns14Tg; nns25Tg + MO2-scn1lab standard conditions Figure 4 with image from Brenet et al., 2019
optic tectum calcium ion transmembrane transport increased magnitude, abnormal zf498Tg/zf498Tg + MO1-spi1b + MO2-scn1lab standard conditions Figure 4 with image from Brenet et al., 2024
optic tectum neuronal action potential increased magnitude, abnormal zf498Tg/zf498Tg + MO1-spi1b + MO2-scn1lab standard conditions Figure 4 with image from Brenet et al., 2024
optic tectum calcium ion transmembrane transport increased frequency, abnormal zf498Tg/zf498Tg + MO1-spi1b + MO2-scn1lab standard conditions Figure 4 with image from Brenet et al., 2024
swimming behavior increased duration, exacerbated WT + MO1-spi1b + MO2-scn1lab standard conditions Figure 5 with image from Brenet et al., 2024
Citations
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