Morpholino

MO1-wls

ID

ZDB-MRPHLNO-101011-2

Name

MO1-wls

Previous Names

None

Target

wls (1)

Sequence

5' - CTCAATAATTGCCCCAGCCATTTTC - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

Translation-blocking MO.

Genome Resources

None

Target Location

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-wls

Expressed Gene	Anatomy	Figures
dlx2a	neural crest cell	Fig. 5 from Wu et al., 2015
fgf3	hypothalamus postero-ventral region midbrain hindbrain boundary optic stalk pharyngeal pouch posterior lateral line primordium	Fig. 3 , Fig. 5 from Wu et al., 2015
fgf8a	epiphysis midbrain hindbrain boundary optic stalk otic vesicle	Fig. 3 from Wu et al., 2015
sox9a	chondrocyte cranial cartilage	Fig. 5 from Wu et al., 2015
sox10	neural crest cell	Fig. 5 from Wu et al., 2015
wls	(not) brain (not) whole organism	Fig. 2 from Wu et al., 2015
wnt5b	(not) pharyngeal arch plasma membrane	Fig. 4 from Wu et al., 2015
wnt11f2	pharyngeal arch plasma membrane	Fig. 4 from Wu et al., 2015

Phenotype

Phenotype resulting from MO1-wls

Phenotype	Fish	Figures
brain disorganized, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010
brain malformed, abnormal	AB + MO1-wls	Fig. 2 from Wu et al., 2015
brain development disrupted, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010
ceratobranchial cartilage malformed, abnormal	AB + MO1-wls	Fig. 2 from Wu et al., 2015
ceratohyal cartilage decreased size, abnormal	AB + MO1-wls	Fig. 2 from Wu et al., 2015
ceratohyal cartilage dislocated, abnormal	AB + MO1-wls	Fig. 2 from Wu et al., 2015
embryonic viscerocranium morphogenesis decreased process quality, abnormal	AB + MO1-wls	Fig. 2 , Fig. 3 from Wu et al., 2015
eye decreased size, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010
head decreased size, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010
inner ear malformed, abnormal	AB + MO1-wls	Fig. 2 from Wu et al., 2015
Meckel's cartilage decreased size, abnormal	AB + MO1-wls	Fig. 2 from Wu et al., 2015
Meckel's cartilage dislocated, abnormal	AB + MO1-wls	Fig. 2 from Wu et al., 2015
midbrain hindbrain boundary aplastic, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010
midbrain hindbrain boundary poorly differentiated, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010
otic vesicle decreased size, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010
pharyngeal arch cartilage development decreased process quality, abnormal	AB + MO1-wls	Fig. 7 from Wu et al., 2015
pharyngeal arch cell population proliferation decreased occurrence, abnormal	AB + MO1-wls	Fig. 7 from Wu et al., 2015
pharyngeal arch Wnt protein secretion decreased occurrence, abnormal	AB + MO1-wls	Fig. 4 from Wu et al., 2015
pharyngeal pouch 1 decreased object quality, abnormal	AB + MO1-wls	Fig. 3 from Wu et al., 2015
pharyngeal pouch 2 decreased object quality, abnormal	AB + MO1-wls	Fig. 3 from Wu et al., 2015
post-vent region curved lateral, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010
post-vent region curved ventral, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010
semicircular canal morphology, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010
semicircular canal development disrupted, abnormal	WT + MO1-wls	Fig. 4 from Jin et al., 2010

Phenotype of all Fish created by or utilizing MO1-wls

Phenotype	Fish	Conditions	Figures
inner ear malformed, abnormal	AB + MO1-wls	standard conditions	Fig. 2 from Wu et al., 2015
brain malformed, abnormal	AB + MO1-wls	standard conditions	Fig. 2 from Wu et al., 2015
pharyngeal arch cell population proliferation decreased occurrence, abnormal	AB + MO1-wls	standard conditions	Fig. 7 from Wu et al., 2015
pharyngeal arch Wnt protein secretion decreased occurrence, abnormal	AB + MO1-wls	standard conditions	Fig. 4 from Wu et al., 2015
pharyngeal pouch 2 decreased object quality, abnormal	AB + MO1-wls	standard conditions	Fig. 3 from Wu et al., 2015
embryonic viscerocranium morphogenesis decreased process quality, abnormal	AB + MO1-wls	standard conditions	Fig. 2 , Fig. 3 from Wu et al., 2015
ceratobranchial cartilage malformed, abnormal	AB + MO1-wls	standard conditions	Fig. 2 from Wu et al., 2015
pharyngeal arch cartilage development decreased process quality, abnormal	AB + MO1-wls	standard conditions	Fig. 7 from Wu et al., 2015
ceratohyal cartilage dislocated, abnormal	AB + MO1-wls	standard conditions	Fig. 2 from Wu et al., 2015
Meckel's cartilage decreased size, abnormal	AB + MO1-wls	standard conditions	Fig. 2 from Wu et al., 2015
pharyngeal pouch 1 decreased object quality, abnormal	AB + MO1-wls	standard conditions	Fig. 3 from Wu et al., 2015
Meckel's cartilage dislocated, abnormal	AB + MO1-wls	standard conditions	Fig. 2 from Wu et al., 2015
ceratohyal cartilage decreased size, abnormal	AB + MO1-wls	standard conditions	Fig. 2 from Wu et al., 2015
brain disorganized, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010
semicircular canal development disrupted, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010
brain development disrupted, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010
midbrain hindbrain boundary poorly differentiated, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010
post-vent region curved ventral, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010
otic vesicle decreased size, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010
head decreased size, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010
post-vent region curved lateral, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010
semicircular canal morphology, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010
midbrain hindbrain boundary aplastic, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010
eye decreased size, abnormal	WT + MO1-wls	standard conditions	Fig. 4 from Jin et al., 2010

Citations