Gene
wls
- ID
- ZDB-GENE-040426-2161
- Name
- Wnt ligand secretion mediator
- Symbol
- wls Nomenclature History
- Previous Names
-
- gpr177
- id:ibd2010
- sb:cb610
- wu:fb36d04
- wu:fb44d10
- wu:fb50c06
- zgc:64091
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable Wnt-protein binding activity. Acts upstream of or within several processes, including brain development; chondrocyte activation; and skeletal system development. Predicted to be located in Golgi membrane. Predicted to be active in endomembrane system and organelle membrane. Is expressed in several structures, including central nervous system; head; inner ear; midbrain neural keel; and neural tube. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb610 (29 images)
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| c186 | Allele with one point mutation | Exon 7 | Premature Stop | ENU | |
| fh252 | Allele with one point mutation | Exon 3 | Premature Stop | ENU | |
| la023414Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023415Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa25762 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39773 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| wls_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| zf759 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-wls | Rochard et al., 2016 | |
| MO1-wls | N/A | (2) |
| MO2-wls | N/A | Jin et al., 2010 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Zaki syndrome | Alliance | Zaki syndrome | 619648 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein wntless | Wntless, GOLD domain | Wntless-like, transmembrane domain |
|---|---|---|---|---|---|
| UniProtKB:Q7T357 | InterPro | 542 | |||
| UniProtKB:F2Z4U3 | InterPro | 542 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-132A5 | ZFIN Curated Data | |
| Contains | SNP | rs3727600 | ZFIN Curated Data | |
| Contains | SNP | rs3727601 | ZFIN Curated Data | |
| Encodes | EST | cb610 | Thisse et al., 2001 | |
| Encodes | EST | fb36d04 | ||
| Encodes | EST | fb44d10 | ||
| Encodes | EST | fb50c06 | ||
| Encodes | EST | ibd2010 | ||
| Encodes | cDNA | MGC:64091 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213146 (1) | 2620 nt | ||
| Genomic | GenBank:BX927121 (2) | 177223 nt | ||
| Polypeptide | UniProtKB:F2Z4U3 (1) | 542 aa |
- Yu, E.P.Y., Saxena, V., Perin, S., Ekker, M. (2023) Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt Signaling and Meckel's Cartilage Morphology. Biomolecules. 13(9):
- Brandão, A.S., Bensimon-Brito, A., Lourenço, R., Borbinha, J., Soares, A.R., Jacinto, A. (2019) Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration. Journal of Cell Science. 132(22):
- Ling, I.T., Rochard, L., Liao, E.C. (2017) Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification. Developmental Biology. 421(2):219-232
- Roberson, S., Halpern, M.E. (2017) Convergence of signaling pathways underlying habenular formation and axonal outgrowth. Development (Cambridge, England). 144(14):2652-2662
- Silva, N., Louro, B., Trindade, M., Power, D.M., Campinho, M.A. (2017) Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis. Scientific Reports. 7:16657
- Rochard, L., Monica, S.D., Ling, I.T., Kong, Y., Roberson, S., Harland, R., Halpern, M., Liao, E.C. (2016) Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during zebrafish palate morphogenesis. Development (Cambridge, England). 143:2541-7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kuan, Y.S., Roberson, S., Akitake, C.M., Fortuno, L., Gamse, J., Moens, C., Halpern, M.E. (2015) Distinct requirements for Wntless in habenular development. Developmental Biology. 406(2):117-28
- Wu, B.T., Wen, S.H., Hwang, S.P., Huang, C.J., Kuan, Y.S. (2015) Control of Wnt5b secretion by wntless modulates chondrogenic cell proliferation through fine-tuning fgf3 expression. Journal of Cell Science. 128(12):2328-39
- Gfrerer, L., Shubinets, V., Hoyos, T., Kong, Y., Nguyen, C., Pietschmann, P., Morton, C.C., Maas, R.L., Liao, E.C. (2014) Functional Analysis of SPECC1L in Craniofacial Development and Oblique Facial Cleft Pathogenesis. Plastic and reconstructive surgery. 134:748-759
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