ZFIN Morpholino: MO3-cdk9

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-cdk9

Expressed Gene	Anatomy	Figures
cdk9	whole organism	Fig. 2 from Matrone et al., 2015
gata6	whole organism	Fig. 6 from Matrone et al., 2015
hbbe3	intermediate cell mass of mesoderm	Fig. 5 from Bai et al., 2010

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Phenotype

Phenotype resulting from MO3-cdk9

Phenotype	Fish	Figures
brain apoptotic body increased amount, abnormal	WIK + MO3-cdk9	Fig. 3 from Matrone et al., 2016
cardiac muscle cell decreased amount, abnormal	f1Tg + MO3-cdk9	Fig. 7 from Matrone et al., 2015
cardiac muscle contraction process quality, abnormal	f1Tg + MO3-cdk9	Fig. 3 , Fig. 7, Fig. 8 from Matrone et al., 2015
cardiac muscle tissue regeneration decreased occurrence, abnormal	f1Tg + MO3-cdk9	Fig. 8 from Matrone et al., 2015
cardiac ventricle decreased size, abnormal	f1Tg + MO3-cdk9	Fig. 3 from Matrone et al., 2015

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Phenotype of all Fish created by or utilizing MO3-cdk9

Phenotype	Fish	Conditions	Figures
pericardium edematous, abnormal	WIK + MO3-cdk9	standard conditions	Fig. 2 from Matrone et al., 2016
trunk cell population proliferation decreased occurrence, abnormal	WIK + MO3-cdk9	standard conditions	Fig. 5 from Matrone et al., 2016
forebrain hypoplastic, abnormal	WIK + MO3-cdk9	standard conditions	Fig. 3 from Matrone et al., 2016
whole organism decreased life span, abnormal	WIK + MO3-cdk9	standard conditions	Fig. 1 from Matrone et al., 2016
trunk curved, abnormal	WIK + MO3-cdk9	standard conditions	Fig. 2 from Matrone et al., 2016

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Citations

Include unpublished citations

Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):
Hoodless, L.J., Lucas, C.D., Duffin, R., Denvir, M.A., Haslett, C., Tucker, C.S., Rossi, A.G. (2016) Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo. Scientific Reports. 5:36980
Matrone, G., Mullins, J.J., Tucker, C.S., Denvir, M.A. (2016) Effects of Cyclin Dependent Kinase 9 inhibition on zebrafish larvae. Cell cycle (Georgetown, Tex.). 15(22):3060-3069
Matrone, G., Wilson, K.S., Maqsood, S., Mullins, J.J., Tucker, C.S., Denvir, M.A. (2015) CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart. Journal of Cell Science. 128(24):4560-71
Bai, X., Kim, J., Yang, Z., Jurynec, M.J., Akie, T.E., Lee, J., LeBlanc, J., Sessa, A., Jiang, H., DiBiase, A., Zhou, Y., Grunwald, D.J., Lin, S., Cantor, A.B., Orkin, S.H., and Zon, L.I. (2010) TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 142(1):133-143

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