Gene
cdk9
- ID
- ZDB-GENE-030131-321
- Name
- cyclin-dependent kinase 9 (CDC2-related kinase)
- Symbol
- cdk9 Nomenclature History
- Previous Names
-
- wu:fb22e09
- wu:fc06c02
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; inflammatory response to wounding; and regulation of cardiac muscle cell proliferation. Predicted to be located in PML body and cytoplasm. Predicted to be active in nucleus. Orthologous to human CDK9 (cyclin dependent kinase 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdk9 | (2) | |
| MO1-cdk9 | N/A | Meier et al., 2006 |
| MO2-cdk9 | N/A | Chen et al., 2009 |
| MO3-cdk9 | N/A | (5) |
| MO4-cdk9 | N/A | Wada et al., 2012 |
| MO5-cdk9 | N/A | Wada et al., 2012 |
| MO6-cdk9 | N/A | Wada et al., 2012 |
| MO7-cdk9 | N/A | Wada et al., 2012 |
| MO8-cdk9 | N/A | Wada et al., 2012 |
| MO9-cdk9 | N/A | Wada et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclin-dependent kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXE8 | InterPro | 374 | |||||
| UniProtKB:A0AB32TAF2 | InterPro | 395 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab3-cdk9 | monoclonal | IgG | Rabbit |
|
Cell Signaling Technology, Inc.
|
3 |
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-93M18 | ZFIN Curated Data | |
| Contains | SNP | rs3729067 | ZFIN Curated Data | |
| Encodes | EST | eu149 | Thisse et al., 2005 | |
| Encodes | EST | fb22e09 | ||
| Encodes | EST | fc06c02 | ||
| Encodes | EST | IMAGE:7163467 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66392 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212591 (1) | 1734 nt | ||
| Genomic | GenBank:BX530036 (2) | 211643 nt | ||
| Polypeptide | UniProtKB:A0AB32TAF2 (1) | 395 aa |
- Belt, A.J., Grant, S., Tombes, R.M., Rothschild, S.C. (2024) Myeloid Targeted Human MLL-ENL and MLL-AF9 Induces cdk9 and bcl2 Expression in Zebrafish Embryos. PLoS Genetics. 20:e1011308e1011308
- Huang, M., Ahmed, A., Wang, W., Wang, X., Ma, C., Jiang, H., Li, W., Jing, L. (2022) Negative Elongation Factor (NELF) Inhibits Premature Granulocytic Development in Zebrafish. International Journal of Molecular Sciences. 23(7):
- Kaveh, A., Bruton, F.A., Oremek, M.E.M., Tucker, C.S., Taylor, J.M., Mullins, J.J., Rossi, A.G., Denvir, M.A. (2021) Selective CDK9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish. Development (Cambridge, England). 149(8):
- Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):
- Sun, Y., Liu, Z., Cao, X., Lu, Y., Mi, Z., He, C., Liu, J., Zheng, Z., Li, M.J., Li, T., Xu, D., Wu, M., Cao, Y., Li, Y., Yang, B., Mei, C., Zhang, L., Chen, Y. (2019) Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease. Science advances. 5:eaaw3593
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hoodless, L.J., Lucas, C.D., Duffin, R., Denvir, M.A., Haslett, C., Tucker, C.S., Rossi, A.G. (2016) Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo. Scientific Reports. 5:36980
- Matrone, G., Mullins, J.J., Tucker, C.S., Denvir, M.A. (2016) Effects of Cyclin Dependent Kinase 9 inhibition on zebrafish larvae. Cell cycle (Georgetown, Tex.). 15(22):3060-3069
- Yang, Q., Liu, X., Zhou, T., Cook, J., Nguyen, K., Bai, X. (2016) RNA polymerase II pausing differentially regulates signaling pathway genes to control hematopoietic stem cell emergence in zebrafish. Blood. 128(13):1701-10
- Matrone, G., Wilson, K.S., Maqsood, S., Mullins, J.J., Tucker, C.S., Denvir, M.A. (2015) CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart. Journal of Cell Science. 128(24):4560-71
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