ZFIN Morpholino: MO2-pbx4

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-pbx4

No data available

Phenotype

Phenotype resulting from MO2-pbx4

No data available

Phenotype of all Fish created by or utilizing MO2-pbx4

Phenotype	Fish	Conditions	Figures
cardiac muscle myoblast cdkn2c expression decreased amount, abnormal	fb7Tg + MO2-pbx4 + MO3-pbx4	standard conditions	Fig. 4 from Holowiecki et al., 2020
cardiac muscle myoblast cdkn1a expression decreased amount, abnormal	fb7Tg + MO2-pbx4 + MO3-pbx4	standard conditions	Fig. 4 from Holowiecki et al., 2020
margin aldh1a2 expression decreased distribution, abnormal	pbx4^b557/b557 + MO1-pbx2 + MO2-pbx2 + MO2-pbx4 + MO3-pbx4	standard conditions	Fig. 8 from Selland et al., 2018
optic tectum decreased size, abnormal	pbx4^b557/b557 + MO1-pbx2 + MO2-pbx2 + MO2-pbx4 + MO3-pbx4	standard conditions	Fig. 1 from Erickson et al., 2007
cerebellum malformed, abnormal	pbx4^b557/b557 + MO1-pbx2 + MO2-pbx2 + MO2-pbx4 + MO3-pbx4	standard conditions	Fig. 1 from Erickson et al., 2007

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Citations

Include unpublished citations

Holowiecki, A., Linstrum, K., Ravisankar, P., Chetal, K., Salomonis, N., Waxman, J.S. (2020) Pbx4 limits heart size and fosters arch artery formation through partitioning second heart field progenitors and restricting proliferation. Development (Cambridge, England). 147(5):
Itoh, T., Takeuchi, M., Sakagami, M., Asakawa, K., Sumiyama, K., Kawakami, K., Shimizu, T., Hibi, M. (2020) Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish. Development (Cambridge, England). 147(19):
Selland, L.G., Koch, S., Laraque, M., Waskiewicz, A.J. (2018) Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development. Mechanisms of Development. 150:28-41
Choe, S.K., Ladam, F., and Sagerström, C.G. (2014) TALE factors poise promoters for activation by Hox proteins. Developmental Cell. 28(2):203-211
Zigman, M., Laumann-Lipp, N., Titus, T., Postlethwait, J., and Moens, C.B. (2014) Hoxb1b controls oriented cell division, cell shape and microtubule dynamics in neural tube morphogenesis. Development (Cambridge, England). 141(3):639-649
Yao, Z., Farr, G.H., Tapscott, S.J., and Maves, L. (2013) Pbx and Prdm1a transcription factors differentially regulate subsets of the fast skeletal muscle program in zebrafish. Biology Open. 2(6):546-555
Erickson, T., Pillay, L.M., and Waskiewicz, A.J. (2011) Zebrafish Tshz3b negatively regulates Hox function in the developing hindbrain. Genesis (New York, N.Y. : 2000). 49(9):725-42
Lukowski, C.M., Drummond, D.L., and Waskiewicz, A.J. (2011) Pbx-dependent regulation of lbx gene expression in developing zebrafish embryos. Genome. 54(12):973-85
Pillay, L.M., Forrester, A.M., Erickson, T., Berman, J.N., and Waskiewicz, A.J. (2010) The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis. Developmental Biology. 340(2):306-317
Maves, L., Tyler, A., Moens, C.B., and Tapscott, S.J. (2009) Pbx acts with Hand2 in early myocardial differentiation. Developmental Biology. 333(2):409-418

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