Morpholino

MO2-isl1a

ID

ZDB-MRPHLNO-060728-1

Name

MO2-isl1a

Previous Names

islet1E2 (1)
MO2-isl1

Target

isl1a (1)

Sequence

5' - TTAATCTGCGTTACCTGATGTAGTC - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-isl1a

Expressed Gene	Anatomy	Figures
bmp4	atrioventricular canal bulbus arteriosus (not) sinus venosus	Fig. 8 from Colombo et al., 2017
ddc	dopaminergic neuron ventral telencephalon dopaminergic neuron	Fig. 6 from Filippi et al., 2012
isl1a	whole organism	Fig. S5 from Hoffmann et al., 2013
shox2	brain	Fig. S6 from Hoffmann et al., 2013
slc6a3	dopaminergic neuron ventral telencephalon dopaminergic neuron	Fig. 6 from Filippi et al., 2012
th	dopaminergic neuron ventral telencephalon dopaminergic neuron	Fig. 6 from Filippi et al., 2012

Phenotype

Phenotype resulting from MO2-isl1a

Phenotype	Fish	Figures
blood accumulation pericardium, abnormal	WT + MO2-isl1a	Fig. 4 from Hoffmann et al., 2013
heart decreased functionality, abnormal	WT + MO2-isl1a	Fig. 4 from Hoffmann et al., 2013
heart contraction decreased occurrence, abnormal	WT + MO2-isl1a	Fig. 4 from Hoffmann et al., 2013
heart contraction disrupted, abnormal	WT + MO2-isl1a	Fig. 4 from Hoffmann et al., 2013
pericardium edematous, abnormal	WT + MO2-isl1a	Fig. 4 from Hoffmann et al., 2013
regulation of heart contraction disrupted, abnormal	WT + MO2-isl1a	Fig. 4 from Hoffmann et al., 2013
sinus venosus bmp4 expression absent, abnormal	WT + MO2-isl1a	Fig. 8 from Colombo et al., 2017

Phenotype of all Fish created by or utilizing MO2-isl1a

Phenotype	Fish	Conditions	Figures
motor neuron axon mislocalised posteriorly, abnormal	AB + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 4 from Hutchinson et al., 2006
VeLD increased amount, abnormal	AB + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 4 from Hutchinson et al., 2006
Kolmer-Agduhr neuron increased amount, abnormal	AB + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 4 from Hutchinson et al., 2006
heart decreased functionality, abnormal	WT + MO2-isl1a	standard conditions	Fig. 4 from Hoffmann et al., 2013
heart contraction disrupted, abnormal	WT + MO2-isl1a	standard conditions	Fig. 4 from Hoffmann et al., 2013
blood accumulation pericardium, abnormal	WT + MO2-isl1a	standard conditions	Fig. 4 from Hoffmann et al., 2013
heart contraction decreased occurrence, abnormal	WT + MO2-isl1a	standard conditions	Fig. 4 from Hoffmann et al., 2013
sinus venosus bmp4 expression absent, abnormal	WT + MO2-isl1a	standard conditions	Fig. 8 from Colombo et al., 2017
regulation of heart contraction disrupted, abnormal	WT + MO2-isl1a	standard conditions	Fig. 4 from Hoffmann et al., 2013
pericardium edematous, abnormal	WT + MO2-isl1a	standard conditions	Fig. 4 from Hoffmann et al., 2013
secondary motor neuron axon decreased amount, abnormal	WT + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 3 from Hutchinson et al., 2006
secondary motor neuron decreased amount, abnormal	WT + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 3 from Hutchinson et al., 2006
secondary motor neuron axon disorganized, abnormal	WT + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 3 from Hutchinson et al., 2006
MiP motor neuron axon absent, abnormal	WT + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 2 from Hutchinson et al., 2006
CaP motoneuron axon absent, abnormal	WT + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 2 from Hutchinson et al., 2006
sinus venosus bmp4 expression absent, abnormal	nkx2.7^vu413/vu413 + MO2-isl1a	standard conditions	Fig. 8 from Colombo et al., 2017
secondary motor neuron absent, abnormal	WT + MO1-isl2a + MO2-isl1a + MO3-isl1a	standard conditions	Fig. 3 from Hutchinson et al., 2006

Citations