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Ameen et al., 2025 - Mutation of the GDP-Fucose Biosynthesis Gene gmds Increases Hair Cell Number and Neuromast Regenerative Capacity in Zebrafish

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Figure 3

No change in neuromast genetic markers or neural innervation in gmds^−/− mutants. Expression level of the gmds gene at 3 dpf shows downregulation in homozygous mutants when compared to control siblings (A,B). No changes are observed in the expression of slc17a8 (C,D), the neuromast-specific fucosyltransferase fut9b (E,F) or the support cell specific sox2 (G,H) between gmds^−/− and control siblings at 3 dpf. In situ hybridization experiment was repeated three times for each genetic marker (WT n = 15, gmds^−/− n = 15), with pictures at 40X. Neuromasts are innervated, with both gmds^−/− and control siblings staining positive for Hnk-1 (I,J, pictures taken at 200X) and acetylated tubulin (K,L, pictures taken at 630X) using immunohistochemistry from two independent experiments (WT n = 6, gmds^−/− n = 6). Arrows point to nerve innervation in K and L.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.