Gene

gmds

ID
ZDB-GENE-050419-45
Name
GDP-mannose 4,6-dehydratase
Symbol
gmds Nomenclature History
Previous Names
  • si:ch211-231n5.3
  • srn
  • towhead (1)
  • twd (1)
  • zgc:63772
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Exhibits fucosyltransferase activity. Involved in Notch signaling pathway; central nervous system development; and retina layer formation. Predicted to localize to cytoplasm. Is expressed in EVL; corneal epithelium; neuromast; and periderm. Used to study congenital disorder of glycosylation type IIc. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gmds Human Ortholog
No data available
Associated With gmds Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR016040 NAD(P)-binding domain
Family IPR006368 GDP-mannose 4,6-dehydratase
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations