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Galuh et al., 2025 - The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner

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Figure 4

Modulation of GR-mediated transactivation and transrepression of genes by zbtb16ab in zebrafish larvae. Five dpf WT zebrafish larvae and zbtb16ab crispants (n = 10–30) were treated with vehicle or 5 μg/mL cortisol for 20 h. Cortisol-induced GR target genes are indicated in the first panels at the upper row: (A) fkbp5 (P = 0.0002), (B) gilz (P = 0.01), (C) pck1 (P = 0.001). (D) Total glucose levels (mean ± S.E.M) from whole-body lysates of either 5 dpf WT zebrafish larvae or zbtb16ab crispants, with increased levels in the cortisol-treated crispants (P = 0.0002). The lower row shows the relative gene expression of GR-repressive genes: (E) nr3c1, (F) il6, (G) pparg, (H) il8 (P = 0.02). The relative gene expression was normalized to actb as a housekeeping gene. Data are presented in geometric means ± geometric S.D. G: genotype, I: interaction, ns: not significant, T: treatment.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Endocrinol.