Gene
il16
- ID
- ZDB-GENE-130103-3
- Name
- interleukin 16
- Symbol
- il16 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable CD4 receptor binding activity and cytokine activity. Predicted to be involved in cytokine-mediated signaling pathway and positive regulation of inflammatory response. Predicted to be located in cytoplasm; extracellular region; and nucleus. Human ortholog(s) of this gene implicated in asthma; colorectal adenocarcinoma; and prostate cancer. Orthologous to human IL16 (interleukin 16).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Interleukin-16-like | PDZ domain | PDZ superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PPE7 | InterPro | 1340 | |||
| UniProtKB:A0A0G2KD61 | InterPro | 1521 | |||
| UniProtKB:A0A8M9QCG1 | InterPro | 1540 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021477711 (1) | 8063 nt | ||
| Genomic | GenBank:CABZ01068274 (1) | 43954 nt | ||
| Polypeptide | UniProtKB:A0A8M9QCG1 (1) | 1540 aa |
- Su, H., Weng, S., Luo, L., Sun, Q., Lin, T., Ma, H., He, Y., Wu, J., Wang, H., Zhang, W., Xu, Y. (2024) Mycobacterium tuberculosis hijacks host macrophages-derived interleukin 16 to block phagolysosome maturation for enhancing intracellular growth. Emerging microbes & infections. 13(1):2322663
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Liu, P., Wang, S., Chang, Z., Li, L., Xing, H., Dong, W.F. (2020) Combined toxicity of silica nanoparticles and cadmium chloride on the cardiovascular system of zebrafish (Danio rerio) larvae. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 239:108895
- Garg, A.D., Vandenberk, L., Fang, S., Fasche, T., Van Eygen, S., Maes, J., Van Woensel, M., Koks, C., Vanthillo, N., Graf, N., de Witte, P., Van Gool, S., Salven, P., Agostinis, P. (2017) Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing. Cell death and differentiation. 24:832-843
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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