Gene
fkbp5
- ID
- ZDB-GENE-030616-630
- Name
- FKBP prolyl isomerase 5
- Symbol
- fkbp5 Nomenclature History
- Previous Names
-
- si:zc263a23.8
- wu:fc31g11
- wu:fl87b03
- zgc:64082
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be active in cytoplasm. Is expressed in gut; head; liver; and regenerating fin. Human ortholog(s) of this gene implicated in alcohol dependence; heroin dependence; and major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64082 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fkbp5 | Zebrafish Nomenclature Committee | |
| CRISPR2-fkbp5 | Li et al., 2023 | |
| CRISPR3-fkbp5 | Li et al., 2023 | |
| CRISPR4-fkbp5 | Li et al., 2023 | |
| CRISPR5-fkbp5 | Li et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| melancholic depression | Alliance | {Major depressive disorder and accelerated response to antidepressant drug treatment} | 608516 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001179 | FKBP-type peptidyl-prolyl cis-trans isomerase domain |
| Family | IPR050754 | Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR046357 | Peptidyl-prolyl cis-trans isomerase domain superfamily |
| Repeat | IPR019734 | Tetratricopeptide repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | FKBP-type peptidyl-prolyl cis-trans isomerase domain | Peptidyl-prolyl cis-trans isomerase domain superfamily | Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ATH6 | InterPro | 326 | |||||
| UniProtKB:Q801U5 | InterPro | 453 | |||||
| UniProtKB:A0A8M2BDK0 | InterPro | 477 | |||||
| UniProtKB:A0A8M9QF85 | InterPro | 457 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-263A23 | ZFIN Curated Data | |
| Encodes | EST | fc31g11 | ZFIN Curated Data | |
| Encodes | EST | fl87b03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64082 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213149 (1) | 2886 nt | ||
| Genomic | GenBank:AL732567 (1) | 152840 nt | ||
| Polypeptide | UniProtKB:A0A8M2BDK0 (1) | 477 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | FKBP5 | 6 | Amino acid sequence comparison (1) |
- Choi, M.K., Cook, A., Mungikar, K., Eachus, H., Tochwin, A., Linke, M., Gerber, S., Ryu, S. (2024) Exposure to elevated glucocorticoid during development primes altered transcriptional responses to acute stress in adulthood. iScience. 27:110160110160
- Lesport, E., Commeau, L., Genet, M., Baulieu, E.E., Tawk, M., Giustiniani, J. (2024) A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo. Frontiers in Cellular Neuroscience. 18:14252221425222
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Allers, M., Bakker, P.A., Hoeksma, J., Spaink, H.P., den Hertog, J. (2023) Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae. Disease models & mechanisms. 16(2):
- Drepanos, L., Gans, I.M., Grendler, J., Guitar, S., Fuqua, J.H., Maki, N.J., Tilden, A.R., Graber, J.H., Coffman, J.A. (2023) Loss of Krüppel-like factor 9 deregulates both physiological gene expression and development. Scientific Reports. 13:1223912239
- Eachus, H., Oberski, L., Paveley, J., Bacila, I., Ashton, J.P., Esposito, U., Seifuddin, F., Pirooznia, M., Elhaik, E., Placzek, M., Krone, N., Cunliffe, V.T. (2023) Glucocorticoid Receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain. Disease models & mechanisms. 16(9):
- Li, Y., Liu, C., Bai, X., Li, M., Duan, C. (2023) FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. FEBS letters. 597(14):1868-1879
- Luckner, B., Essfeld, F., Ayobahan, S.U., Richling, E., Eilebrecht, E., Eilebrecht, S. (2023) Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression. Ecotoxicology and environmental safety. 266:115570115570
- Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., Liu, H. (2023) Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and environmental safety. 259:115020115020
- Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G. (2023) Stress resilience is established during development and is regulated by complement factors. Cell Reports. 42:111973111973
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