ZFIN is now using GRCz12tu for Genomic Data
Gene
fkbp5
- ID
- ZDB-GENE-030616-630
- Name
- FKBP prolyl isomerase 5
- Symbol
- fkbp5 Nomenclature History
- Previous Names
-
- si:zc263a23.8
- wu:fc31g11
- wu:fl87b03
- zgc:64082
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be active in cytoplasm. Is expressed in gut; head; liver; and regenerating fin. Human ortholog(s) of this gene implicated in alcohol dependence; heroin dependence; and major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64082 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| major depressive disorder | Alliance | {Major depressive disorder and accelerated response to antidepressant drug treatment} | 608516 |
| melancholic depression | Alliance | {Major depressive disorder and accelerated response to antidepressant drug treatment} | 608516 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001179 | FKBP-type peptidyl-prolyl cis-trans isomerase domain |
| Family | IPR050754 | Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR046357 | Peptidyl-prolyl cis-trans isomerase domain superfamily |
| Repeat | IPR019734 | Tetratricopeptide repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | FKBP-type peptidyl-prolyl cis-trans isomerase domain | Peptidyl-prolyl cis-trans isomerase domain superfamily | Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ATH6 | InterPro | 326 | |||||
| UniProtKB:Q801U5 | InterPro | 453 | |||||
| UniProtKB:A0A8M2BDK0 | InterPro | 477 | |||||
| UniProtKB:A0A8M9QF85 | InterPro | 457 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers