Gene

fkbp5

ID

ZDB-GENE-030616-630

Name

FKBP prolyl isomerase 5

Symbol

fkbp5 Nomenclature History

Previous Names

si:zc263a23.8
wu:fc31g11
wu:fl87b03
zgc:64082

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and protein peptidyl-prolyl isomerization. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in major depressive disorder. Is expressed in gut; head; and regenerating fin. Orthologous to human FKBP5 (FKBP prolyl isomerase 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

24 figures from 17 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64082 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fkbp5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
melancholic depression	Alliance	{Major depressive disorder and accelerated response to antidepressant drug treatment}	608516

Associated With fkbp5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily
Repeat	IPR019734	Tetratricopeptide repeat

Domain Details Per Protein

Protein	Length	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Peptidyl-prolyl cis-trans isomerase domain superfamily	Tetratricopeptide-like helical domain superfamily	Tetratricopeptide repeat
UniProtKB:A0A8M3ATH6 InterPro	326
UniProtKB:Q801U5 InterPro	453
UniProtKB:A0A8M2BDK0 InterPro	477
UniProtKB:A0A8M9QF85 InterPro	457

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fkbp5-201 (1) Ensembl	Ensembl	2,613 nt	Select Tool ZFIN BLAST
mRNA	fkbp5-203 (1) Ensembl	Ensembl	3,634 nt	Select Tool ZFIN BLAST
ncRNA	fkbp5-002 (1) Ensembl	Ensembl	917 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations