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Xiao et al., 2025 - Hsf1 is essential for proteotoxic stress response in smyd1b-deficient embryos and fish survival under heat shock

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Fig. 2 Upregulation of heat shock protein gene expression in smyd1b mutant zebrafish embryos. Hsp70 chaperone and cochaperone gene expression was analyzed in smyd1bsa15678 mutant embryos by in situ hybridization and qRT-PCR at 24 hpf. Compared to the control groups (A, C, E, G, I, K, M), a muscle-specific upregulation of expression was detected for hsp70.1/2/l (B), hsp70.3 (D), hspa1b (F), hsc70 (H), hspa8b (J), hsph1 (L), and dnaja (N) in the smyd1bsa15678 mutant embryos. All larvae are side view, with anterior left and dorsal up. (O–T) Data of qRT-PCR analysis show quantified changes of hsp70.1/2/l (O), hsp70.3 (P), hspa1b (Q), hsc70 (R), hspa8b (S), hsph1 (T) gene expression in smyd1b mutant embryos compared with WT control. * and ** indicate significant difference. Scale bar = 100 μm.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ FASEB J.