Gene

hsp70.3

ID

ZDB-GENE-110713-1

Name

heat shock cognate 70-kd protein, tandem duplicate 3

Symbol

hsp70.3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Acts upstream of or within camera-type eye morphogenesis. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1A (heat shock protein family A (Hsp70) member 1A); and HSPA1B (heat shock protein family A (Hsp70) member 1B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hsp70.3 Human Ortholog

No data available

Associated With hsp70.3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018181	Heat shock protein 70, conserved site
Family	IPR013126	Heat shock protein 70 family
Homologous_superfamily	IPR029047	Heat shock protein 70kD, peptide-binding domain superfamily
Homologous_superfamily	IPR029048	Heat shock protein 70kD, C-terminal domain superfamily
Homologous_superfamily	IPR043129	ATPase, nucleotide binding domain