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Li et al., 2025 - Peptidoglycan recognition protein PGRP-5 is involved in immune defence and neuro-behavioral disorders in zebrafish embryos

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Fig 5 The pro-inflammatory cytokines were mainly inhibited but anti-inflammatory genes were significantly activated in zebrafish embryos under PGRP5-KD conditions.

(A) The relative mRNA levels of IL-1β at 6, 24, 48, and 72 hpf both in the mock and PGRP5-KD conditions. (B) The relative mRNA levels of IL-6 at 6, 24, 48, and 72 hpf both in the mock and PGRP5-KD conditions. (C) The relative mRNA levels of TNF-α at 6, 24, 48, and 72 hpf both in the mock and PGRP5-KD conditions. (D) The relative mRNA levels of TGF-β at 6, 24, 48, and 72 hpf both in the mock and PGRP5-KD conditions. The values in each group were presented as means ± SEM (Each value contains at least four biological replicates, and each biological replicate contains three technical replicates). For all experiments, *p < 0.05 and **p <0 .01 for intra-group comparison; #p < 0.05 and ##p <0 .01 for inter-group comparison.

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