ZFIN Image: Jia et al., 2022, Fig. 5

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Figure Caption

Fig. 5

Ferroptosis signaling pathway was activated in tulp1-dKO zebrafish.

A KEGG pathway enrichment analysis of the genes identified to be differentially expressed between wt and tulp1-dKO groups. The significantly enriched pathways are shown. B GSEA of ferroptosis-related genes. C–H Relative expression of genes involved in ferroptosis was detected by qRT-PCR at 4 dpf. Mean ± SD. *P < 0.05. **P < 0.01. Lipid droplets performed by Nile Red (I) or BODIPY (J) in wt and tulp1-dKO zebrafish at 4 dpf. Enlarged images of the boxed areas are shown in the lower right corner. Scale bar: 20 µm. K Perls/DAB staining in wt and tulp1-dKO zebrafish at 4 dpf. Enlarged images of the boxed areas are shown beneath. Scale bar: 25 µm. L TEM images of mitochondria from wt and tulp1-dKO zebrafish. M, mitochondria. OS, outer segment. Scale bar: 0.2 µm.

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Acknowledgments

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