Gene
alox5b.3
- ID
- ZDB-GENE-050522-330
- Name
- arachidonate 5-lipoxygenase b, tandem duplicate 3
- Symbol
- alox5b.3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable arachidonate 5-lipoxygenase activity. Predicted to be involved in arachidonate metabolic process; lipid oxidation; and lipoxygenase pathway. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in EVL; head; and periderm. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb171 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027664Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa17737 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42462 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR020833 | Lipoxygenase, iron binding site |
| Conserved_site | IPR020834 | Lipoxygenase, conserved site |
| Domain | IPR001024 | PLAT/LH2 domain |
| Domain | IPR013819 | Lipoxygenase, C-terminal |
| Family | IPR000907 | Lipoxygenase |
| Family | IPR001885 | Lipoxygenase, mammalian |
| Homologous_superfamily | IPR036226 | Lipoxigenase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036392 | PLAT/LH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Lipoxigenase, C-terminal domain superfamily | Lipoxygenase | Lipoxygenase, conserved site | Lipoxygenase, C-terminal | Lipoxygenase, iron binding site | Lipoxygenase, mammalian | PLAT/LH2 domain | PLAT/LH2 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R442 | InterPro | 676 | ||||||||
| UniProtKB:Q503R7 | InterPro | 676 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
alox5b.3-201
(1)
|
Ensembl | 2,576 nt | ||
| mRNA |
alox5b.3-204
(1)
|
Ensembl | 4,090 nt | ||
| ncRNA |
alox5b.3-002
(1)
|
Ensembl | 434 nt | ||
| ncRNA |
alox5b.3-003
(1)
|
Ensembl | 962 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-144D13 | ZFIN Curated Data | |
| Encodes | EST | cb171 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:110251 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191740 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020578 (1) | 2580 nt | ||
| Genomic | GenBank:CU469509 (1) | 105182 nt | ||
| Polypeptide | UniProtKB:F1R442 (1) | 676 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ALOX5 | 10 | Amino acid sequence comparison (1) |
- Sun, S.X., Liu, Y.C., Limbu, S.M., Li, D.L., Chen, L.Q., Zhang, M.L., Yin, Z., Du, Z.Y. (2023) Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(4):159289
- Jia, D., Gao, P., Lv, Y., Huang, Y., Reilly, J., Sun, K., Han, Y., Hu, H., Chen, X., Zhang, Z., Li, P., Luo, J., Shu, X., Tang, Z., Liu, F., Liu, M., Ren, X. (2022) Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish. Cell Death & Disease. 13:962
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Adel, S., Heydeck, D., Kühn, H., Ufer, C. (2016) The lipoxygenase pathway in zebrafish. Expression and characterization of zebrafish ALOX5 and comparison with its human ortholog. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1861(1):1-11
- Chatzopoulou, A., Heijmans, J.P., Burgerhout, E., Oskam, N., Spaink, H.P., Meijer, A.H., Schaaf, M.J. (2016) Glucocorticoid-induced attenuation of the inflammatory response in zebrafish. Endocrinology. 157(7):2772-84
- Tyrkalska, S.D., Candel, S., Angosto, D., Gómez-Abellán, V., Martín-Sánchez, F., García-Moreno, D., Zapata-Pérez, R., Sánchez-Ferrer, Á., Sepulcre, M.P., Pelegrín, P., Mulero, V. (2016) Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins. Nature communications. 7:12077
- Adel, S., Hofheinz, K., Heydeck, D., Kuhn, H., Häfner, A.K. (2014) Phosphorylation mimicking mutations of ALOX5 orthologs of different vertebrates do not alter reaction specificities of the enzymes. Biochimica et biophysica acta. Molecular basis of disease. 1842(10):1460-6
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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