Gene
ptgs2b
- ID
- ZDB-GENE-041014-323
- Name
- prostaglandin-endoperoxide synthase 2b
- Symbol
- ptgs2b Nomenclature History
- Previous Names
-
- Cox-2b (1)
- si:dkey-97o5.6
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables peroxidase activity. Predicted to be involved in cyclooxygenase pathway. Predicted to act upstream of or within fatty acid biosynthetic process; prostaglandin metabolic process; and response to oxidative stress. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and neuron projection. Is expressed in several structures, including female organism; gonad; kidney; male organism; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; arthritis (multiple); cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Haem peroxidase, animal-type | Haem peroxidase domain superfamily, animal type | Haem peroxidase superfamily | Oxylipin biosynthesis and metabolism |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RI06 | InterPro | 606 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptgs2b-201
(1)
|
Ensembl | 2,556 nt |
Interactions and Pathways
No data available
Plasmids
No data available