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Fig. 3
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Fig. 3
Collagen IV expression during optic fissure formation and fusion. A) WISH for zebrafish collagen IV (col4) genes a1-a6 at 24hpf. At 24hpf, only collagen IV a1 and a2 had optic fissure expression (yellow arrow heads). Col4 a3-a6 were all detected in the retinal periphery and in the developing lens. B) WISH time course for col4 a1 and a2 expression from 24 to 65hpf. Both col4 a1 and a2 had detectable expression in the optic fissure up to 56hpf (yellow arrow heads).
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Reprinted from Developmental Biology, 452(1), Nicholas, C., Weaver, M., Piedade, W.P., Vocking, O., Famulski, J.K., Temporal characterization of optic fissure basement membrane composition suggests nidogen may be an initial target of remodeling, 43-54, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.