Gene

col4a4

ID

ZDB-GENE-101001-1

Name

collagen, type IV, alpha 4

Symbol

col4a4 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within glomerular basement membrane development and glomerular filtration. Predicted to be located in basement membrane and extracellular region. Predicted to be part of collagen trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including gill; gonad primordium; hypodermis; lens; and pronephros. Used to study Alport syndrome. Human ortholog(s) of this gene implicated in autosomal recessive Alport syndrome; benign familial hematuria; and end stage renal disease. Orthologous to human COL4A4 (collagen type IV alpha 4 chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Naylor et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With col4a4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive Alport syndrome	Alliance	Alport syndrome 2, autosomal recessive	203780
benign familial hematuria	Alliance	Hematuria, familial benign, 1	141200

Associated With col4a4 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Alport syndrome	WT + CRISPR1-col4a4 + CRISPR2-col4a4 + CRISPR3-col4a4 + CRISPR4-col4a4	standard conditions	Naylor et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001442	Collagen IV, non-collagenous
Family	IPR050149	Collagen superfamily
Homologous_superfamily	IPR016187	C-type lectin fold
Homologous_superfamily	IPR036954	Collagen IV, non-collagenous domain superfamily
Repeat	IPR008160	Collagen triple helix repeat

Domain Details Per Protein

Protein	Length	Collagen IV, non-collagenous	Collagen IV, non-collagenous domain superfamily	Collagen superfamily	Collagen triple helix repeat	C-type lectin fold
UniProtKB:X1WFR7 InterPro	1670

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	col4a4-201 (1) Ensembl	Ensembl		10,607 nt	Select Tool ZFIN BLAST
mRNA	col4a4-202 (1) Ensembl	Ensembl		723 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations