Gene

col4a5

ID

ZDB-GENE-030131-2281

Name

collagen, type IV, alpha 5 (Alport syndrome)

Symbol

col4a5 Nomenclature History

Previous Names

dragnet (1)
drg
wu:fc02g11

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to be an extracellular matrix structural constituent. Acts upstream of or within axonogenesis and basement membrane organization. Predicted to be located in extracellular region and membrane. Predicted to be part of collagen trimer. Predicted to be active in basement membrane and extracellular space. Is expressed in several structures, including digestive system; integument; nervous system; neural tube; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alport syndrome and X-linked Alport syndrome. Orthologous to human COL4A5 (collagen type IV alpha 5 chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu2431 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With col4a5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
X-linked Alport syndrome	Alliance	Alport syndrome 1, X-linked	301050

Associated With col4a5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001442	Collagen IV, non-collagenous
Family	IPR050149	Collagen superfamily
Homologous_superfamily	IPR016187	C-type lectin fold
Homologous_superfamily	IPR036954	Collagen IV, non-collagenous domain superfamily
Repeat	IPR008160	Collagen triple helix repeat