Gene

col4a6

ID

ZDB-GENE-101001-2

Name

collagen, type IV, alpha 6

Symbol

col4a6 Nomenclature History

Previous Names

im:7147757
shiomaneki (1)
sio

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to be an extracellular matrix structural constituent. Acts upstream of or within axon extension involved in axon guidance and basement membrane organization. Predicted to be located in extracellular region and membrane. Predicted to be part of collagen trimer. Predicted to be active in basement membrane and extracellular space. Is expressed in several structures, including head; hypodermis; solid lens vesicle; swim bladder; and swim bladder bud. Human ortholog(s) of this gene implicated in AMME complex and X-linked deafness 6. Orthologous to human COL4A6 (collagen type IV alpha 6 chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147757 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With col4a6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
X-linked deafness 6	Alliance	?Deafness, X-linked 6	300914

Associated With col4a6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001442	Collagen IV, non-collagenous
Family	IPR050149	Collagen superfamily
Homologous_superfamily	IPR016187	C-type lectin fold
Homologous_superfamily	IPR036954	Collagen IV, non-collagenous domain superfamily
Repeat	IPR008160	Collagen triple helix repeat

Domain Details Per Protein

Protein	Length	Collagen IV, non-collagenous	Collagen IV, non-collagenous domain superfamily	Collagen superfamily	Collagen triple helix repeat	C-type lectin fold
UniProtKB:A0A8M9QD06 InterPro	1688
UniProtKB:A0A8M3B4D5 InterPro	1686
UniProtKB:A0A8M6Z091 InterPro	1714
UniProtKB:A0A8M6Z7E0 InterPro	1717
UniProtKB:A0A8M6Z1T7 InterPro	1700

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	col4a6-201 (1) Ensembl	Ensembl	5,145 nt	Select Tool ZFIN BLAST
mRNA	col4a6-202 (1) Ensembl	Ensembl	8,255 nt	Select Tool ZFIN BLAST
mRNA	col4a6-203 (1) Ensembl	Ensembl	5,001 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations