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Gath et al., 2019 - Zebrafish mab21l2 mutants possess severe defects in optic cup morphogenesis, lens and cornea development

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Fig. 2

mab21l2^−/− mutants possess delays in lens morphogenesis and lens growth, and do not properly express markers of mature lens cell types. A‐N: Transverse sections of wild‐type (A‐G) and mab21l2^−/− mutant (H‐N) embryos showing lens development over time. Compared with wild‐type, mab21l2^−/− mutants do not show induction of lens morphogenesis at 18SS (H); instead, comparable development is not detected until 22SS (I). Lenses remain smaller at 28 hpf (K), 36 hpf (L), 48 hpf (M), and 5 dpf (N). Note pyknotic nuclei in 28 hpf mutant (K, arrowhead). O‐Z: Whole‐mount in situ hybridizations of 48 hpf wild‐type (O‐T) and mab21l2^−/− (U‐Z) embryos. Note apparently reduced tgfβ3 (U), prox1 (X), and celf1 (Y) in mab21l2^−/− mutants, compared with wild‐type (O,R,S, respectively). Note also that mab21l2^−/− mutants lack detectable pitx3 (V), foxe3 (w), and cryaa(Z) expression. Dorsal is up in all panels. Scale bars = 50 μm

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