Gene
foxe3
- ID
- ZDB-GENE-061214-6
- Name
- forkhead box E3
- Symbol
- foxe3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within aorta development; lens morphogenesis in camera-type eye; and negative regulation of lens fiber cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including adenohypophyseal placode; hatching gland; lens; lens placode; and optic primordium. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 2; cataract 34 multiple types; and thoracic aortic aneurysm. Orthologous to human FOXE3 (forkhead box E3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| s4001 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-foxe3 | Krall et al., 2018 | |
| MO1-foxe3 | N/A | Shi et al., 2006 |
| MO2-foxe3 | N/A | Shi et al., 2006 |
| MO3-foxe3 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anterior segment dysgenesis 2 | Alliance | Anterior segment dysgenesis 2, multiple subtypes | 610256 |
| cataract 34 multiple types | Alliance | Cataract 34, multiple types | 612968 |
| congenital aphakia | Alliance | Anterior segment dysgenesis 2, multiple subtypes | 610256 |
| {Aortic aneurysm, familial thoracic 11, susceptibility to} | 617349 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box domain-containing protein | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0UXI3 | InterPro | 422 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(foxe3:NLS-EGFP) |
|
| 1 | Taler et al., 2019 | |
| Tg(foxe3:vps45-GFP) |
|
| 1 | Mochizuki et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-281K2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-99I20 | ||
| Encodes | cDNA | MGC:194751 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194769 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079682 (1) | 1648 nt | ||
| Genomic | GenBank:FP016062 (2) | 109334 nt | ||
| Polypeptide | UniProtKB:B0UXI3 (1) | 422 aa |
- Ceroni, F., Cicekdal, M.B., Holt, R., Sorokina, E., Chassaing, N., Clokie, S., Naert, T., Talbot, L.V., Muheisen, S., Bax, D.A., Kesim, Y., Kivuva, E.C., Vincent-Delorme, C., Lienkamp, S.S., Plaisancié, J., De Baere, E., Calvas, P., Vleminckx, K., Semina, E.V., Ragge, N.K. (2024) Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development. Nature communications. 15:92459245
- Posner, M., Garver, T., Kaye, T., Brdicka, S., Suttle, M., Patterson, B., Farnsworth, D.R. (2024) Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens. Experimental Eye Research. 244:109918
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
- Posner, M., Murray, K.L., Andrew, B., Brdicka, S., Roberts, A., Franklin, K., Hussen, A., Kaye, T., Kepp, E., McDonald, M.S., Snodgrass, T., Zientek, K., David, L.L. (2022) Impact of α-crystallin protein loss on zebrafish lens development. Experimental Eye Research. 227:109358
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Hsiao, T.H., Lee, G.H., Chang, Y.S., Chen, B.H., Fu, T.F. (2021) The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects. Frontiers in cell and developmental biology. 9:702969
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Gath, N., Gross, J.M. (2019) Zebrafish mab21l2 mutants possess severe defects in optic cup morphogenesis, lens and cornea development. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(7):514-529
- Taler, K., Weiss, O., Rotem, S., Rubinstein, A.M., Seritrakul, P., Gross, J.M., Inbal, A. (2019) Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate. Developmental Biology. 458(2):177-188
- Krall, M., Htun, S., Anand, D., Hart, D., Lachke, S.A., Slavotinek, A.M. (2018) A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans. Human genetics. 137(4):315-328
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