ZFIN Image: Lu et al., 2015, Fig. 8

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Figure Caption

Fig. 8

Combined knockdown of irf7 and p53 restores decreased HSPCs in 142^{T −/−} embryos. (a and b) Injection of irf7 MO with p53 MO rescued the decreased expression of HSPCs marker runx1, and the extent of the restoration was greater than the single injection of irf7 MO at 26 and 36 hpf (mean±s.d., n=5, *P<0.05). (c) The increased expression of p53 was not affected in 142^T−/− embryos injected with irf7 MO at 26 and 36 hpf by qPCR (each sample was composed at least 40 embryos, mean±s.d., n=3, *P<0.05, **P<0.01, ns stands for no significance). (d) The increased expression of irf7 was not affected in 142^T−/− embryos injected with p53 MO at 26 hpf, 2 and 4 dpf by qPCR (mean±s.d., n=3, *P<0.05, **P<0.01, ns stands for no significance).

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Acknowledgments

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