Gene

irf7

ID
ZDB-GENE-040426-1518
Name
interferon regulatory factor 7
Symbol
irf7 Nomenclature History
Previous Names
  • wu:fl24c03
  • zgc:66043
  • zgc:77947
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Exhibits transcription regulatory region DNA binding activity. Involved in hemopoiesis; regulation of hemopoiesis; and response to virus. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in alar plate midbrain region; nervous system; otic vesicle; pronephric duct; and ventral wall of dorsal aorta. Orthologous to human IRF7 (interferon regulatory factor 7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irf7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 39 Alliance ?Immunodeficiency 39 616345
Associated With irf7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001346 Interferon regulatory factor DNA-binding domain
Domain IPR019471 Interferon regulatory factor-3
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Interferon regulatory factor-3 Interferon regulatory factor DNA-binding domain SMAD/FHA domain superfamily SMAD-like domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q6PE40 423
UniProtKB:F1QNG2 422
UniProtKB:H0WFC4 377
UniProtKB:Q6NZY9 382
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations