Fig. 4
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Fig. 4
mecp2 negatively regulates her2 expression to control neural cell differentiation. (A–D′′) neurod, huc and islet1 decreased in mecp2 morphants (A′–D′), and this was partially rescued by co-injection of her2-MO (A′′–D′′), compared with controls (A–D). The expression of neurod increased in her2 morphants (A′′′,B′′′), compared with the wild-type (WT) (A,B). Dorsal views, with anterior to the left (A–D′). The numbers in the bottom right corner represent the number of embryos showing the indicated phenotype/total embryos examined. (E) Quantitative real-time PCR analysis of related gene expression in wild-type embryos and her2 morphants, normalized to gapdh. The data represent the mean±s.d. of three independent experiments. *P<0.05.