Gene

gfap

ID
ZDB-GENE-990914-3
Name
glial fibrillary acidic protein
Symbol
gfap Nomenclature History
Previous Names
  • af506734 (1)
  • cb345 (1)
  • etID36982.3 (1)
  • wu:fb34h11 (1)
  • wu:fk42c12
  • xx:af506734 (1)
  • zgc:110485
  • zrf-1 antigen (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable structural molecule activity. Located in cytoplasm and type III intermediate filament. Is expressed in several structures, including anterior neural keel; nervous system; neural tube; neuronal stem cell; and optic vesicle. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
95 figures from 63 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gfap Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alexander disease Alliance Alexander disease 203450
Associated With gfap Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018039 Intermediate filament protein, conserved site
Domain IPR006821 Intermediate filament head, DNA-binding domain
Domain IPR039008 Intermediate filament, rod domain
Family IPR002957 Keratin, type I
Family IPR027701 Glial fibrillary acidic protein
Homologous_superfamily IPR042180 Intermediate filament, rod domain, coil 1B
Domain Details Per Protein
Protein Length Glial fibrillary acidic protein Intermediate filament head, DNA-binding domain Intermediate filament protein, conserved site Intermediate filament, rod domain Intermediate filament, rod domain, coil 1B Keratin, type I
UniProtKB:C5IG44 164
UniProtKB:Q8JIY5 360
UniProtKB:F1RAE8 444
UniProtKB:B2GP50 444
UniProtKB:Q58EE9 444
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-gfap monoclonal IgG1 Mouse
  • IHC
Dako North America, Inc.
Abcam plc
MP Biomedicals
3
zrf-1 monoclonal IgG1 Mouse
  • IHC
Zebrafish International Resource Center (ZIRC)  (order this)
111
Ab21-gfap polyclonal IgG Rabbit
  • WB
NSJ Bioreagents
2
Ab2-gfap polyclonal Rabbit
  • IHC
Dako North America, Inc.
36
Ab4-gfap polyclonal Rabbit
  • IHC
6
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations