Gene
gfap
- ID
- ZDB-GENE-990914-3
- Name
- glial fibrillary acidic protein
- Symbol
- gfap Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in intermediate filament organization and regulation of chaperone-mediated autophagy. Located in cytoplasm and type III intermediate filament. Is expressed in several structures, including anterior neural keel; nervous system; neural tube; neuronal stem cell; and optic vesicle. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 119 figures from 80 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb345 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Alexander disease | Alliance | Alexander disease | 203450 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Intermediate filament head, DNA-binding domain | Intermediate filament protein, conserved site | Intermediate filament, rod domain | Intermediate filament structural protein | Keratin, type I |
|---|---|---|---|---|---|---|
|
UniProtKB:Q58EE9
|
444 | |||||
|
UniProtKB:F1RAE8
|
444 | |||||
|
UniProtKB:B2GP50
|
444 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gfap | monoclonal | IgG1 | Mouse |
|
Dako North America, Inc.
Abcam plc MP Biomedicals |
3 | |
| zrf-1 | monoclonal | IgG1 | Mouse |
|
Zebrafish International Resource Center (ZIRC)
(
order this
)
|
138 | |
| Ab21-gfap | polyclonal | IgG | Rabbit |
|
NSJ Bioreagents
|
2 | |
| Ab2-gfap | polyclonal | Rabbit |
|
Dako North America, Inc.
|
46 | ||
| Ab4-gfap | polyclonal | Rabbit |
|
6 |
Plasmids