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Fig. 8 AML1-ETO downregulates scl, leading to the early effects of AML1-ETO expression in primitive hematopoietic cells. (A) In situ hybridization of scl. AML1-ETO expression results in scl downregulation specifically in hematopoietic cells. The expression of scl in the head (asterisk), in the endothelial primordium (arrowhead), and in the posterior tail region (arrow) was not affected. (B) In situ hybridization of gata1, mpo and fluorescent images of zpu.1-EGFP transgenic zebrafish. Injections of scl mRNA restored gata1 expression and reversed pu.1 and mpo induction in Tg(hsp:AML1-ETO) embryos.
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