ZFIN ID: ZDB-GENE-990615-5
Gene Name: T-box transcription factor 16
Gene Symbol: tbx16    Nomenclature History

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Previous Names: cb103 (1), id:ibd2185 (1), spadetail, spt-1 (1), spt (1), wu:fa17g07 (1), ZF-SPT (1), zgc:109817

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits transcription regulatory region DNA binding activity. Involved in several processes, including animal organ development; blood vessel morphogenesis; and regulation of embryonic development. Localizes to the nuclear chromatin. Is expressed in several structures, including forerunner cell group; germ ring; mesoderm; presumptive mesoderm; and spinal cord.
Genome Resources: Alliance (1),  Gene:30264 (1),  Ensembl(GRCz11):ENSDARG00000007329 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b104 Indel Unknown Premature Stop SPONTANEOUS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi2109Tg Transgenic Insertion Intron 1 Unknown DNA
    hi3714Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • kt378b Point Mutation Acceptor Splice Site of Intron 1 Unknown ENU
    la016429Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026643Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026644Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029508Tg Transgenic Insertion Unknown Unknown DNA
    m423 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tbx16_unspecified Unspecified Unknown Unknown
    thp003 Point Mutation Unknown Missense ENU
    tm41 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tq5 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tbx16
    3
    CRISPR2-tbx16
    2
    CRISPR3-tbx16
    1
    CRISPR4-tbx16
    1
    CRISPR5-tbx16
    1
    CRISPR6-tbx16
    1
    MO1-tbx16 N/A 11
    MO2-tbx16 N/A 11
    MO3-tbx16 N/A 11
    MO4-tbx16 N/A 2
    MO5-tbx16 N/A 1
    MO6-tbx16 N/A 2
    PHENOTYPE
    Data: 59 figures from 32 publications
    Observed in:
    DISEASE ASSOCIATED WITH tbx16 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tbx16 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process digestive tract development (more)
    Cellular Component nuclear chromatin (more)
    Molecular Function DNA binding (more)
    GO Terms (all 41)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018186 Transcription factor, T-box, conserved site
    Family IPR001699 Transcription factor, T-box
    Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
    Homologous_superfamily IPR036960 T-box superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbx16-201 (1)    Ensembl 4949
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB3-tbx16 monoclonal IgG2a Mouse 1
    Ab2-tbx16 polyclonal Mouse IHC 3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbx16
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.2tbx16:TagRFP) tbx16 TagRFP Danio rerio 1 1
    Tg(-1.2tbx16:TagRFP,cryaa:GFP) cryaatbx16 GFPTagRFP Danio rerio 1 1
    Tg(HSE:tbx16-MYC,EGFP) EGFPtbx16 Danio rerio 1 2
    Tg(hsp70l:tbx16-2A-NLS-KikGR) hsp70l 2AKikGRNLStbx16 Danio rerio 1 1
    Tg(hsp70l:tbx16-ENR-2A-NLS-KikGR) hsp70l 2AENRKikGRNLStbx16 Danio rerio 1 1
    Tg(tbx16:EGFP) tbx16 EGFP Danio rerio 4 5
    Tg(tbx16:mRFP) tbx16 mRFP Danio rerio 1 1
    Tg2(hsp70l:tbx16-2A-NLS-KikGR) hsp70l 2AKikGRNLStbx16 Danio rerio 1 1
    MARKER RELATIONSHIPS
    tbx16 Contained in: [BAC] CH73-313L22 (1)
    tbx16 Encodes: [EST] cb103 (1) (order this), fa17g07 (1), ibd2185
    [STS] chunp30288
    [cDNA] MGC:109817 (1), MGC:193075 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131058 (1) 2561 nt
    Genomic GenBank:CU459194 (1) 101559 nt
    Select Tool
    Polypeptide UniProtKB:B8JL25 (1) 470 aa
    Sequence Information (all 23)
    ORTHOLOGY for tbx16 ( Chr: 8 )
    CITATIONS (255)