Gene
opn1mw4
- ID
- ZDB-GENE-990604-43
- Name
- opsin 1 (cone pigments), medium-wave-sensitive, 4
- Symbol
- opn1mw4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to act upstream of or within signal transduction and visual perception. Predicted to be located in membrane. Predicted to be active in photoreceptor outer segment and plasma membrane. Is expressed in several structures, including endocrine system; gut; heart; integument; and visual system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20786 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor opsins | G protein-coupled receptor, rhodopsin-like | Opsin | Rhodopsin | Rhodopsin, N-terminal | Visual pigments (opsins) retinal binding site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W6A6 | InterPro | 349 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
opn1mw4-201
(1)
|
Ensembl | 1,379 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(lcr.opn-krt4:EGFP,opn1mw4:RFP) |
| 1 | Tsujimura et al., 2015 | ||
| Tg(lcr.opn-opn1mw1:EGFP,opn1mw4:RFP) |
| 1 | Tsujimura et al., 2015 | ||
| Tg(lcr.opn-opn1mw3:EGFP,opn1mw4:RFP) |
| 1 | Tsujimura et al., 2015 | ||
| Tg(lcr.opn-opn1mw4:EGFP) |
|
| 1 | Tsujimura et al., 2015 | |
| Tg(lcr.opn-opn1mw4:EGFP,opn1mw3:RFP) |
| 1 | Tsujimura et al., 2015 | ||
| Tg(opn1mw4:EGFP) |
|
| 1 | (3) | |
| TgPAC(lcr.opn-opn1mw3:GFP,opn1mw4:RFP) |
| 1 | Tsujimura et al., 2015 | ||
| TgPAC(lcr.opn-opn1mw4:GFP) |
|
| 1 | Tsujimura et al., 2015 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-263A23 | ZFIN Curated Data | |
| Encodes | EST | fk64b02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73141 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131254 (1) | 1398 nt | ||
| Genomic | GenBank:AL732567 (2) | 152840 nt | ||
| Polypeptide | UniProtKB:Q9W6A6 (1) | 349 aa |
No data available
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Lu, K., Liang, X.F., Tang, S.L., Wu, J., Zhang, L., Wang, Y., Chai, F. (2023) Role of short-wave-sensitive 1 (sws1) in cone development and first feeding in larval zebrafish. Fish physiology and biochemistry. 49(5):801-813
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
- Zhang, J., Jing, M., Li, P., Sun, L., Pi, X., Jiang, N., Zhu, K.K., Li, H., Li, J., Wang, M., Zhang, J., Liu, M., Mu, H., Hu, Y., Cui, X. (2023) Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1869(4):166645
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Liu, F., Qin, Y., Huang, Y., Gao, P., Li, J., Yu, S., Jia, D., Chen, X., Lv, Y., Tu, J., Sun, K., Han, Y., Reilly, J., Shu, X., Lu, Q., Tang, Z., Xu, C., Luo, D., Liu, M. (2022) Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS Genetics. 18:e1009841
- Shi, W.J., Long, X.B., Li, S.Y., Ma, D.D., Liu, F., Zhang, J.G., Lu, Z.J., Ying, G.G. (2022) Dydrogesterone and levonorgestrel at environmentally relevant concentrations have antagonist effects with rhythmic oscillation in brain and eyes of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 248:106177
- Liang, Q., Afriyie, G., Chen, Z., Xu, Z., Dong, Z., Wang, Z., Guo, Y. (2021) Analysis of Opsin Gene Family of Crimson Snapper (Lutjanus erythropterus). Gene. 807:145960
- Deveau, C., Jiao, X., Suzuki, S.C., Krishnakumar, A., Yoshimatsu, T., Hejtmancik, J.F., Nelson, R.F. (2020) Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish). PLoS Genetics. 16:e1008869
- Shi, W.J., Huang, G.Y., Jiang, Y.X., Ma, D.D., Chen, H.X., Huang, M.Z., Hou, L.P., Xie, L., Ying, G.G. (2020) Medroxyprogesterone acetate affects eye growth and the transcription of associated genes in zebrafish. Ecotoxicology and environmental safety. 193:110371
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