Gene
alcama
- ID
- ZDB-GENE-990415-30
- Name
- activated leukocyte cell adhesion molecule a
- Symbol
- alcama Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Involved in several processes, including cartilage morphogenesis; neural crest cell differentiation; and positive regulation of cell morphogenesis. Acts upstream of or within axonogenesis; embryonic organ morphogenesis; and retina morphogenesis in camera-type eye. Located in axon. Is expressed in several structures, including digestive system; immature eye; musculature system; nervous system; and pericardial region. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 183 figures from 106 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55230 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns201 | Allele with one deletion | Exon 10 | Unknown | TALEN | |
| bns244 | Allele with one deletion | Promoter | Unknown | CRISPR | |
| la011841Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12510 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34926 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-alcama | El-Brolosy et al., 2019 | |
| CRISPR2-alcama | El-Brolosy et al., 2019 | |
| CRISPR3-alcama | Murayama et al., 2023 | |
| CRISPR4-alcama | Murayama et al., 2023 | |
| MO1-alcama | N/A | (3) |
| MO2-alcama | N/A | Diekmann et al., 2009 |
| MO3-alcama | N/A | (2) |
| MO4-alcama | N/A | Choudhry et al., 2011 |
| MO5-alcama | N/A | Konzer et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013106 | Immunoglobulin V-set domain |
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Domain Details Per Protein
| Protein | Length | CD80-like, immunoglobulin C2-set | Cell Surface Receptors and Adhesion Molecules | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | Immunoglobulin subtype 2 | Immunoglobulin V-set domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8PV55
|
555 | |||||||||
|
UniProtKB:Q90460
|
564 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
alcama-201
(1)
|
Ensembl | 3,112 nt | ||
| mRNA |
alcama-202
(1)
|
Ensembl | 1,902 nt | ||
| mRNA |
alcama-203
(1)
|
Ensembl | 2,058 nt | ||
| mRNA | ottdart00000004183 (1) | Havana | 1,145 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-alcama | polyclonal | Rabbit |
|
4 | |||
| zn-5 | monoclonal | IgG1 , k | Mouse |
|
Zebrafish International Resource Center (ZIRC)
(
order this
)
|
237 | |
| Ab3-alcama | monoclonal | Mouse |
|
3 | |||
| Ab1-alcama | monoclonal | IgG | Mouse |
|
2 | ||
| zn-8 | monoclonal | IgG1 , k | Mouse |
|
Developmental Studies Hybridoma Bank
Zebrafish International Resource Center (ZIRC) ( order this ) |
219 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(nkx2.3:alcama-EGFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-222J15 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-17K08 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-25N23 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-39L02 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-71O15 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d215 | Bushell et al., 2007 | |
| Encodes | cDNA | cssl:d822 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:55230 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85602 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131000 (1) | 2057 nt | ||
| Genomic | GenBank:BX537347 (1) | 197064 nt | ||
| Polypeptide | UniProtKB:Q90460 (1) | 564 aa |
- da Silva, A.R., Gunawan, F., Boezio, G.L.M., Faure, E., Théron, A., Avierinos, J.F., Lim, S., Jha, S.G., Ramadass, R., Guenther, S., Looso, M., Zaffran, S., Juan, T., Stainier, D.Y.R. (2024) egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. Science advances. 10:eadl0633
- Murayama, E., Vivier, C., Schmidt, A., Herbomel, P. (2023) Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis. Nature communications. 14:11711171
- Jiang, Z., El-Brolosy, M.A., Serobyan, V., Welker, J.M., Retzer, N., Dooley, C.M., Jakutis, G., Juan, T., Fukuda, N., Maischein, H.M., Balciunas, D., Stainier, D.Y.R. (2022) Parental mutations influence wild-type offspring via transcriptional adaptation. Science advances. 8:eabj2029
- Perl, E., Ravisankar, P., Beerens, M.E., Mulahasanovic, L., Smallwood, K., Sasso, M.B., Wenzel, C., Ryan, T.D., Komár, M., Bove, K.E., MacRae, C.A., Weaver, K.N., Prada, C.E., Waxman, J.S. (2022) Stx4 is required to regulate cardiomyocyte Ca2+ handling during vertebrate cardiac development. HGG advances. 3:100115
- Gentile, A., Bensimon-Brito, A., Priya, R., Maischein, H.M., Piesker, J., Guenther, S., Gunawan, F., Stainier, D.Y. (2021) The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression. eLIFE. 10:
- Paolini, A., Fontana, F., Pham, V.C., Rödel, C.J., Abdelilah-Seyfried, S. (2021) Mechanosensitive Notch-Dll4 and Klf2-Wnt9 signaling pathways intersect in guiding valvulogenesis in zebrafish. Cell Reports. 37:109782
- Peng, X., Feng, G., Zhang, Y., Sun, Y. (2021) PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction. International Journal of Molecular Sciences. 22(21):
- Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
- Liu, Y.H., Lin, T.C., Hwang, S.L. (2020) Zebrafish Pax1a and Pax1b are required for pharyngeal pouch morphogenesis and ceratobranchial cartilage development. Mechanisms of Development. 161:103598
- Wang, M., Du, L., Lee, A.C., Li, Y., Qin, H., He, J. (2020) Different lineage contexts direct common pro-neural factors to specify distinct retinal cell subtypes. The Journal of cell biology. 219(9):
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