Gene

alcama

ID

ZDB-GENE-990415-30

Name

activated leukocyte cell adhesion molecule a

Symbol

alcama Nomenclature History

Previous Names

alcam (1)
cd166 (1)
DM-GRASP (1)
neurolin-a (1)
neurolin (1)
zn5 / zn-5 antigen (1)
zn8 / zn-8 antigen

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Enables identical protein binding activity. Involved in several processes, including cartilage morphogenesis; neural crest cell differentiation; and positive regulation of cell morphogenesis involved in differentiation. Acts upstream of or within axonogenesis; embryonic organ morphogenesis; and retina morphogenesis in camera-type eye. Located in axon. Is expressed in several structures, including digestive system; immature eye; musculature system; nervous system; and pericardial region. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

181 figures from 105 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55230 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alcama Human Ortholog

No data available

Associated With alcama Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013106	Immunoglobulin V-set domain
Domain	IPR013162	CD80-like, immunoglobulin C2-set
Family	IPR051116	Cell Surface Receptors and Adhesion Molecules
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	CD80-like, immunoglobulin C2-set	Cell Surface Receptors and Adhesion Molecules	Immunoglobulin domain subtype	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin/major histocompatibility complex, conserved site	Immunoglobulin subtype 2	Immunoglobulin V-set domain
UniProtKB:A0A2R8PV55 InterPro	555
UniProtKB:Q90460 InterPro	564

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	alcama-201 (1) Ensembl	Ensembl	3,112 nt	Select Tool ZFIN BLAST
mRNA	alcama-202 (1) Ensembl	Ensembl	1,902 nt	Select Tool ZFIN BLAST
mRNA	alcama-203 (1) Ensembl	Ensembl	2,058 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000004183 (1)	Havana	1,145 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-alcama	polyclonal	alcama		Rabbit	IHC		4
zn-5	monoclonal	alcama	IgG1 , k	Mouse	IHC WB	Zebrafish International Resource Center (ZIRC) ( order this )	236
Ab3-alcama	monoclonal	alcama		Mouse	IHC		3
Ab1-alcama	monoclonal	alcama	IgG	Mouse	WB		2
zn-8	monoclonal	alcama	IgG1 , k	Mouse	IHC	Developmental Studies Hybridoma Bank Zebrafish International Resource Center (ZIRC) ( order this )	219

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations