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ZIRC
ZFIN ID: ZDB-GENE-980526-115
Gene Name: nuclear receptor subfamily 2, group F, member 1a
Gene Symbol: nr2f1a    Nomenclature History

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Previous Names: nr2f1, COUP(VI), couptf6, COUPTFalpha-A (1), etID309751.5 (1), seven-up related 44, svp44 (1), wu:fc10d05 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in circulatory system development and endothelial cell proliferation. Predicted to localize to the nucleus. Is expressed in several structures, including basal plate midbrain region; cardiovascular system; mesoderm; nervous system; and pharyngeal arch. Orthologous to human NR2F1 (nuclear receptor subfamily 2 group F member 1).
Genome Resources: Alliance (1),  Gene:30418 (1),  Ensembl(GRCz11):ENSDARG00000052695 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ci1009 Small Deletion Exon 2 Premature Stop CRISPR
el512 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
sa11358 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14691 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20527 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40551 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45227 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nr2f1a 1
    MO1-nr2f1a N/A 1
    MO2-nr2f1a N/A 1
    MO3-nr2f1a N/A 1
    TALEN1-nr2f1a 1
    DISEASE ASSOCIATED WITH nr2f1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Bosch-Boonstra-Schaaf optic atrophy syndrome 615722
    DISEASE ASSOCIATED WITH nr2f1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process atrial cardiac muscle cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 18)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nr2f1a-201 (1)    Ensembl 2994
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-nr2f1a polyclonal Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nr2f1a No data available
    MARKER RELATIONSHIPS
    nr2f1a Contained in: [BAC] DKEYP-10A3 (1)
    nr2f1a Encodes: [EST] fc10d05 (1)
    [cDNA] MGC:65769 (1) (order this), MGC:76864 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131180 (1) 2937 bp
    Genomic GenBank:CR751602 (1) 65729 bp
    Select Tool
    Polypeptide UniProtKB:Q06725 (1) 411 aa
    Sequence Clusters UniGene:16 (1)
    Sequence Information (all 24)
    ORTHOLOGY for nr2f1a ( Chr: 5 )
    CITATIONS (49)