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ZIRC
ZFIN ID: ZDB-GENE-050810-2
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Gene Name: calpastatin
Gene Symbol: cast    Nomenclature History

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Previous Names: sb:cb966 (1), zgc:194249

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have calcium-dependent cysteine-type endopeptidase inhibitor activity. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); congenital myasthenic syndrome 1A; pemphigus; rheumatoid arthritis; and vasculitis. Is expressed in several structures, including digestive system; embryonic structure; epidermis; pectoral fin; and periderm. Orthologous to human CAST (calpastatin).
Genome Resources: Alliance (1),  Gene:563084 (1),  Ensembl(GRCz11):ENSDARG00000058693 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 2 publications
Directly Submitted Expression Data: 6 figures (7 images) from Thisse et al., 2001 [cb966]
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010507Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa3122 Point Mutation Unknown Premature Stop ENU
    sa8530 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa11266 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa14469 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa14830 Point Mutation Unknown Premature Stop ENU
    sa15221 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa23868 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa29534 Point Mutation Unknown Premature Stop ENU
    sa39318 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa43593 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cast HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 616295
    DISEASE ASSOCIATED WITH cast VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Molecular Function calcium-dependent cysteine-type endopeptidase inhibitor activity (more)
    GO Terms (all 1)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001259 (1)
  • InterPro:IPR026998 (1)
  • Pfam:PF00748 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cast-202 (1)    Ensembl 710
    Select Tool
    cast-203 (1)    Ensembl 3766
    Select Tool
    cast-204 (1)    Ensembl 1062
    Select Tool
    cast-205 (1)    Ensembl 895
    Select Tool
    cast-207 (1)    Ensembl 729
    Select Tool
    cast-208 (1)    Ensembl 645
    Select Tool
    cast-209 (1)    Ensembl 977
    Select Tool
    cast-211 (1)    Ensembl 462
    Select Tool
    cast-212 (1)    Ensembl 762
    Select Tool
    cast-213 (1)    Ensembl 843
    Select Tool
    cast-214 (1)    Ensembl 398
    Select Tool
    cast-215 (1)    Ensembl 576
    Select Tool
    cast-216 (1)    Ensembl 747
    Select Tool
    ncRNA cast-014 (1)    Ensembl 328
    Select Tool
    cast-015 (1)    Ensembl 467
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cast No data available
    MARKER RELATIONSHIPS
    cast Contained in: [BAC] DKEY-6B12 (1) (order this), DKEY-93M12 (1) (order this), DKEY-184P9 (1) (order this)
    cast Encodes: [EST] cb966 (1) (order this)
    [cDNA] MGC:194249 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001130591 (1) 2561 bp
    Select Tool
    Genomic GenBank:BX511081 (1) 210246 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QZT8 (1) 839 aa
    Select Tool
    Sequence Clusters UniGene:77085 (1)
    Sequence Information (all 101)
    ORTHOLOGY for cast ( Chr: 21 )
    CITATIONS (31)