ZFIN is now using GRCz12tu for Genomic Data

Gene

cast

ID

ZDB-GENE-050810-2

Name

calpastatin

Symbol

cast Nomenclature History

Previous Names

sb:cb966 (1)
zgc:194249

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable calcium-dependent cysteine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; embryonic structure; epidermis; pectoral fin; and periderm. Human ortholog(s) of this gene implicated in several diseases, including PLACK syndrome; Sjogren's syndrome; autoimmune disease of musculoskeletal system (multiple); congenital myasthenic syndrome 1A; and rheumatoid arthritis. Orthologous to human CAST (calpastatin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb966 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cast Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
PLACK syndrome	Alliance	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads	616295

Associated With cast Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR026998	Calpastatin
Repeat	IPR001259	Proteinase inhibitor I27, calpastatin

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2B7Y5	InterPro	802
UniProtKB:A0A8M9PQJ2	InterPro	734
UniProtKB:A0A8M9PIC6	InterPro	834
UniProtKB:A0A8M9P3E0	InterPro	697
UniProtKB:A0A8M2B800	InterPro	724
UniProtKB:A0A8M6YUH4	InterPro	835
UniProtKB:A0A8M2B7Z9	InterPro	792
UniProtKB:A0A8M9PTZ9	InterPro	720
UniProtKB:A0A8M9P3D7	InterPro	730
UniProtKB:A0A8M2B7Y6	InterPro	734
UniProtKB:A0A8M9PQJ5	InterPro	707
UniProtKB:A0A8M9PCQ8	InterPro	841
UniProtKB:A0A8M6Z304	InterPro	831
UniProtKB:A0A8M3ALB2	InterPro	845
UniProtKB:A0A8M9PTY8	InterPro	818
UniProtKB:A0A8M6YWX8	InterPro	696
UniProtKB:A0A8M1NI55	InterPro	818
UniProtKB:A0A8M9P3D4	InterPro	802
UniProtKB:A0A8M2B7Y0	InterPro	811
UniProtKB:A0A8M2B7Z1	InterPro	757
UniProtKB:F1QZT8	InterPro	839
UniProtKB:A0A8M9PTZ2	InterPro	763
UniProtKB:A0A8M2B7Y7	InterPro	824
UniProtKB:A0A8M2B873	InterPro	733
UniProtKB:A0A8M9PCR3	InterPro	730
UniProtKB:A0A8M9PQI9	InterPro	814
UniProtKB:A0A0R4IPE6	InterPro	835
UniProtKB:A0A8M2B7Z6	InterPro	700
UniProtKB:A0A8M9PID2	InterPro	728
UniProtKB:A0A8M2B865	InterPro	845
UniProtKB:A0A8M9PIC9	InterPro	767
UniProtKB:A0AB32T805	InterPro	703
UniProtKB:A0AB32TEU3	InterPro	828
UniProtKB:A0AB32TEZ7	InterPro	800
UniProtKB:A0AC58I9I7	InterPro	800
UniProtKB:A0AC58I9J7	InterPro	791
UniProtKB:A0AC58I9J8	InterPro	796
UniProtKB:A0AC58I9J9	InterPro	807
UniProtKB:A0AC58I9K0	InterPro	788
UniProtKB:A0AC58I9K1	InterPro	781
UniProtKB:A0AC58I9K2	InterPro	807
UniProtKB:A0AC58I9K6	InterPro	796
UniProtKB:A0AC58I9K8	InterPro	824
UniProtKB:A0AC58I9K9	InterPro	830
UniProtKB:A0AC58I9L1	InterPro	820
UniProtKB:A0AC58I9L2	InterPro	722
UniProtKB:A0AC58I9L4	InterPro	740
UniProtKB:A0AC58I9L5	InterPro	781
UniProtKB:A0AC58I9L6	InterPro	713
UniProtKB:A0AC58I9L7	InterPro	768
UniProtKB:A0AC58I9L8	InterPro	746
UniProtKB:A0AC58I9L9	InterPro	780
UniProtKB:A0AC58I9M0	InterPro	729
UniProtKB:A0AC58I9M2	InterPro	757
UniProtKB:A0AC58I9M3	InterPro	756
UniProtKB:A0AC58I9M4	InterPro	750
UniProtKB:A0AC58I9M5	InterPro	761
UniProtKB:A0AC58I9M7	InterPro	696
UniProtKB:A0AC58I9N1	InterPro	723
UniProtKB:A0AC58I9N2	InterPro	695
UniProtKB:A0AC58I9N4	InterPro	673
UniProtKB:A0AC58I9N8	InterPro	689
UniProtKB:A0AC58I9P0	InterPro	686
UniProtKB:A0AC58I9P1	InterPro	662

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cast-201 (1) Ensembl	Ensembl	2,527 nt	Select Tool ZFIN BLAST
mRNA	cast-202 (1) Ensembl	Ensembl	710 nt	Select Tool ZFIN BLAST
mRNA	cast-203 (1) Ensembl	Ensembl	3,766 nt	Select Tool ZFIN BLAST
mRNA	cast-204 (1) Ensembl	Ensembl	1,062 nt	Select Tool ZFIN BLAST
mRNA	cast-205 (1) Ensembl	Ensembl	895 nt	Select Tool ZFIN BLAST
mRNA	cast-207 (1) Ensembl	Ensembl	729 nt	Select Tool ZFIN BLAST
mRNA	cast-208 (1) Ensembl	Ensembl	645 nt	Select Tool ZFIN BLAST
mRNA	cast-209 (1) Ensembl	Ensembl	977 nt	Select Tool ZFIN BLAST
mRNA	cast-211 (1) Ensembl	Ensembl	462 nt	Select Tool ZFIN BLAST
mRNA	cast-212 (1) Ensembl	Ensembl	762 nt	Select Tool ZFIN BLAST
mRNA	cast-213 (1) Ensembl	Ensembl	843 nt	Select Tool ZFIN BLAST
mRNA	cast-214 (1) Ensembl	Ensembl	398 nt	Select Tool ZFIN BLAST
mRNA	cast-215 (1) Ensembl	Ensembl	576 nt	Select Tool ZFIN BLAST
mRNA	cast-216 (1) Ensembl	Ensembl	747 nt	Select Tool ZFIN BLAST
mRNA	cast-217 (1) Ensembl	Ensembl	2,515 nt	Select Tool ZFIN BLAST
mRNA	cast-218 (1) Ensembl	Ensembl	2,443 nt	Select Tool ZFIN BLAST
mRNA	cast-219 (1) Ensembl	Ensembl	2,734 nt	Select Tool ZFIN BLAST
ncRNA	cast-014 (1) Ensembl	Ensembl	328 nt	Select Tool ZFIN BLAST
ncRNA	cast-015 (1) Ensembl	Ensembl	467 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations