ZFIN ID: ZDB-GENE-050810-2 |
Gene Name: | calpastatin | ||||||
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Gene Symbol: | cast Nomenclature History | ||||||
Previous Names: | sb:cb966 (1), zgc:194249 | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Chr: 21 Mapping Details/Browsers | ||||||
Description: | Predicted to have calcium-dependent cysteine-type endopeptidase inhibitor activity. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); congenital myasthenic syndrome 1A; pemphigus; rheumatoid arthritis; and vasculitis. Is expressed in several structures, including digestive system; embryonic structure; epidermis; pectoral fin; and periderm. Orthologous to human CAST (calpastatin). | ||||||
Genome Resources: | Alliance (1), Gene:563084 (1), Ensembl(GRCz11):ENSDARG00000058693 (2) |
All Expression Data: | 11 figures from 2 publications |
Directly Submitted Expression Data: | 6 figures (7 images) from Thisse et al., 2001 [cb966] |
Wild-type Stages, Structures: | Cleavage:4-cell (1.0h-1.25h) to Hatching:Long-pec (48.0h-60.0h) |
Curated Microarray Expression: | GEO (1) |
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
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Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads | 616295 |
Ontology | GO Term |
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Molecular Function | calcium-dependent cysteine-type endopeptidase inhibitor activity (more) |
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Type | Name | Length (nt) | Analysis | |
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mRNA |
cast-202
(1)
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710 |
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cast-203
(1)
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3766 |
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cast-204
(1)
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1062 |
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cast-205
(1)
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895 |
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cast-207
(1)
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729 |
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||
cast-208
(1)
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645 |
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cast-209
(1)
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977 |
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cast-211
(1)
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462 |
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cast-212
(1)
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762 |
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cast-213
(1)
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843 |
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cast-214
(1)
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398 |
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cast-215
(1)
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576 |
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cast-216
(1)
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747 |
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ncRNA |
cast-014
(1)
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328 |
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cast-015
(1)
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467 |
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Browsers: UCSC, NCBI, Ensembl, ZFIN |
cast Contained in: | [BAC] DKEY-6B12 (1) (order this), DKEY-93M12 (1) (order this), DKEY-184P9 (1) (order this) |
cast Encodes: |
[EST]
cb966 (1) (order this)
[cDNA] MGC:194249 (1) |
Type | Accession # | Length (bp/aa) | Analysis |
---|---|---|---|
RNA | RefSeq:NM_001130591 (1) | 2561 bp |
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Genomic | GenBank:BX511081 (1) | 210246 bp | Blast at MegaBLAST |
Polypeptide | UniProtKB:F1QZT8 (1) | 839 aa |
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Sequence Clusters | UniGene:77085 (1) |