Gene
eif4e1c
- ID
- ZDB-GENE-050417-398
- Name
- eukaryotic translation initiation factor 4E family member 1c
- Symbol
- eif4e1c Nomenclature History
- Previous Names
-
- eif4E-1C (1)
- fb57e09
- wu:fb57e09
- zgc:110154
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110154 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-eif4e1c | Rao et al., 2023 | |
| CRISPR2-eif4e1c | Rao et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Eukaryotic translation initiation factor 4E (eIF-4E), conserved site | Translation Initiation factor eIF- 4e | Translation Initiation factor eIF- 4e-like |
|---|---|---|---|---|---|
| UniProtKB:A9JT06 | InterPro | 213 | |||
| UniProtKB:B8A6A1 | InterPro | 230 | |||
| UniProtKB:Q568Q8 | InterPro | 117 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
eif4e1c-202
(1)
|
Ensembl | 1,645 nt | ||
| mRNA |
eif4e1c-201
(1)
|
Ensembl | 1,815 nt | ||
| mRNA |
eif4e1c-203
(1)
|
Ensembl | 1,005 nt | ||
| mRNA |
eif4e1c-206
(1)
|
Ensembl | 356 nt | ||
| ncRNA |
eif4e1c-002
(1)
|
Ensembl | 868 nt | ||
| ncRNA |
eif4e1c-004
(1)
|
Ensembl | 196 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:3xFLAG-eif4e1c) |
|
| 1 | Lorenzo-Orts et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-228D14 | ZFIN Curated Data | |
| Encodes | EST | fb57e09 | ||
| Encodes | cDNA | MGC:110154 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174301 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192575 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017851 (1) | 1848 nt | ||
| Genomic | GenBank:BX927098 (1) | 229413 nt | ||
| Polypeptide | UniProtKB:B8A6A1 (1) | 230 aa |
No data available
- Lorenzo-Orts, L., Strobl, M., Steinmetz, B., Leesch, F., Pribitzer, C., Roehsner, J., Schutzbier, M., Dürnberger, G., Pauli, A. (2023) eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs. EMBO reports. 25(1):404-427
- Rao, A., Lyu, B., Jahan, I., Lubertozzi, A., Zhou, G., Tedeschi, F., Jankowsky, E., Kang, J., Carstens, B., Poss, K.D., Baskin, K., Goldman, J.A. (2023) The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration. Development (Cambridge, England). 150(20):
- Zhang, Y., Qin, C., Yang, L., Lu, R., Zhao, X., Nie, G. (2018) A comparative genomics study of carbohydrate/glucose metabolic genes: from fish to mammals. BMC Genomics. 19:246
- Frank, D.F., Miller, G.W., Connon, R.E., Geist, J., Lein, P.J. (2017) Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. PeerJ. 5:e4106
- Amemiya, C.T., Alfoldi, J., Lee, A.P., Fan, S., Philippe, H., MacCallum, I., Braasch, I., Manousaki, T., Schneider, I., Rohner, N., Organ, C., Chalopin, D., Smith, J.J., Robinson, M., Dorrington, R.A., Gerdol, M., Aken, B., Biscotti, M.A., Barucca, M., Baurain, D., Berlin, A.M., Blatch, G.L., Buonocore, F., Burmester, T., Campbell, M.S., Canapa, A., Cannon, J.P., Christoffels, A., de Moro, G., Edkins, A.L., Fan, L., Fausto, A.M., Feiner, N., Forconi, M., Gamieldien, J., Gnerre, S., Gnirke, A., Goldstone, J.V., Haerty, W., Hahn, M.E., Hesse, U., Hoffmann, S., Johnson, J., Karchner, S.I., Karaku, S., Lara, M., Levin, J.Z., Litman, G.W., Mauceli, E., Miyake, T., Mueller, M.G., Nelson, D.R., Nitsche, A., Olmo, E., Ota, T., Pallavicini, A., Panji, S., Picone, B., Ponting, C.P., Prohaska, S.J., Przybylski, D., Saha, N.R., Ravi, V., Ribeiro, F.J., Sauka-Spengler, T., Scapigliati, G., Searle, S.M.J., Sharpe, T., Simakov, O., Stadler, P.F., Stegeman, J.J., Sumiyama, K., Tabbaa, D., Tafer, H., Turner-Maier, J., van Heusden, P., White, S., Williams, L., Yandell, M., Brinkmann, H., Volff, J.N., Tabin, C.J., Shubin, N., Schartl, M., Jaffe, D.B., Postlethwait, J.H., Venkatesh, B., Palma, F.D., Lander, E.S., Meyer, A., and Lindblad-Toh, K. (2013) The African coelacanth genome provides insights into tetrapod evolution. Nature. 496:311-316
- Joshi, B., Lee, K., Maeder, D.L., and Jagus, R. (2005) Phylogenetic analysis of eIF4E-family members. BMC Evolutionary Biology. 5:48
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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