ZFIN is now using GRCz12tu for Genomic Data
Gene
nek2
- ID
- ZDB-GENE-040426-752
- Name
- NIMA-related kinase 2
- Symbol
- nek2 Nomenclature History
- Previous Names
-
- zgc:55602
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within retinal rod cell development. Predicted to be located in kinetochore; microtubule cytoskeleton; and nucleolus. Predicted to be active in centrosome and nucleus. Is expressed in gall bladder and liver. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55602 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Nishiguchi et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 67 | Alliance | ?Retinitis pigmentosa 67 | 615565 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NEK Ser/Thr protein kinase family, NIMA subfamily | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUN2 | InterPro | 440 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers