ZFIN is now using GRCz12tu for Genomic Data
Gene
atp2a2a
- ID
- ZDB-GENE-040426-702
- Name
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
- Symbol
- atp2a2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable P-type calcium transporter activity. Acts upstream of or within heart looping; regulation of heart contraction; and regulation of skeletal muscle fiber development. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in cardiovascular system; musculature system; pectoral fin; polster; and somite. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7165932 (1 image)
- MGC:55380 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrokeratosis verruciformis | Alliance | Acrokeratosis verruciformis | 101900 |
| keratosis follicularis | Alliance | Darier disease | 124200 |
| {Rhabdomyolysis, susceptibility to, 2} | 621236 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004014 | Cation-transporting P-type ATPase, N-terminal |
| Domain | IPR006068 | Cation-transporting P-type ATPase, C-terminal |
| Domain | IPR044492 | P-type ATPase, haloacid dehalogenase domain |
| Domain | IPR059000 | P-type ATPase, A domain |
| Family | IPR001757 | P-type ATPase |
| Family | IPR005782 | P-type ATPase, subfamily IIA, SERCA-type |
| Homologous_superfamily | IPR008250 | P-type ATPase, A domain superfamily |
| Homologous_superfamily | IPR023214 | HAD superfamily |
| Homologous_superfamily | IPR023298 | P-type ATPase, transmembrane domain superfamily |
| Homologous_superfamily | IPR023299 | P-type ATPase, cytoplasmic domain N |
| Homologous_superfamily | IPR036412 | HAD-like superfamily |
| PTM | IPR018303 | P-type ATPase, phosphorylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cation-transporting P-type ATPase, C-terminal | Cation-transporting P-type ATPase, N-terminal | HAD-like superfamily | HAD superfamily | P-type ATPase | P-type ATPase, A domain | P-type ATPase, A domain superfamily | P-type ATPase, cytoplasmic domain N | P-type ATPase, haloacid dehalogenase domain | P-type ATPase, phosphorylation site | P-type ATPase, subfamily IIA, SERCA-type | P-type ATPase, transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZW18 | InterPro | 996 | ||||||||||||
| UniProtKB:A0A8M2BEU8 | InterPro | 1042 | ||||||||||||
| UniProtKB:A0A8M9QII7 | InterPro | 996 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
atp2a2a-202
(1)
|
Ensembl | 798 nt | ||
| mRNA |
atp2a2a-201
(1)
|
Ensembl | 3,724 nt | ||
| mRNA |
atp2a2a-203
(1)
|
Ensembl | 3,186 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-atp2a2a | polyclonal | IgG | Rabbit |
|
GeneTex
|
2 |
Plasmids
No data available
- Genome Browsers