ZFIN is now using GRCz12tu for Genomic Data
Gene
atp2a2a
- ID
- ZDB-GENE-040426-702
- Name
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
- Symbol
- atp2a2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable P-type calcium transporter activity. Acts upstream of or within heart looping and regulation of heart contraction. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in cardiovascular system; musculature system; pectoral fin; polster; and somite. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55380 (12 images)
- IMAGE:7165932 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ebert et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrokeratosis verruciformis | Alliance | Acrokeratosis verruciformis | 101900 |
| keratosis follicularis | Alliance | Darier disease | 124200 |
| {Rhabdomyolysis, susceptibility to, 2} | 621236 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004014 | Cation-transporting P-type ATPase, N-terminal |
| Domain | IPR006068 | Cation-transporting P-type ATPase, C-terminal |
| Domain | IPR044492 | P-type ATPase, haloacid dehalogenase domain |
| Family | IPR001757 | P-type ATPase |
| Family | IPR005782 | P-type ATPase, subfamily IIA, SERCA-type |
| Homologous_superfamily | IPR008250 | P-type ATPase, A domain superfamily |
| Homologous_superfamily | IPR023214 | HAD superfamily |
| Homologous_superfamily | IPR023298 | P-type ATPase, transmembrane domain superfamily |
| Homologous_superfamily | IPR023299 | P-type ATPase, cytoplasmic domain N |
| Homologous_superfamily | IPR036412 | HAD-like superfamily |
| PTM | IPR018303 | P-type ATPase, phosphorylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cation-transporting P-type ATPase, C-terminal | Cation-transporting P-type ATPase, N-terminal | HAD-like superfamily | HAD superfamily | P-type ATPase | P-type ATPase, A domain superfamily | P-type ATPase, cytoplasmic domain N | P-type ATPase, haloacid dehalogenase domain | P-type ATPase, phosphorylation site | P-type ATPase, subfamily IIA, SERCA-type | P-type ATPase, transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZW18 | InterPro | 996 | |||||||||||
| UniProtKB:A0A8M2BEU8 | InterPro | 1042 | |||||||||||
| UniProtKB:A0A8M9QII7 | InterPro | 996 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
atp2a2a-202
(1)
|
Ensembl | 798 nt | ||
| mRNA |
atp2a2a-201
(1)
|
Ensembl | 3,724 nt | ||
| mRNA |
atp2a2a-203
(1)
|
Ensembl | 3,186 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-atp2a2a | polyclonal | IgG | Rabbit |
|
GeneTex
|
2 |
Plasmids
No data available
- Genome Browsers