Gene
pak1
- ID
- ZDB-GENE-030826-29
- Name
- p21 protein (Cdc42/Rac)-activated kinase 1
- Symbol
- pak1 Nomenclature History
- Previous Names
-
- cb761 (1)
- wu:fj97h10
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Exhibits identical protein binding activity and protein kinase activity. Involved in several processes, including animal organ development; convergent extension; and dorsal/ventral axis specification. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Is expressed in several structures, including axial mesoderm; cardiovascular system; nervous system; neural tube; and pectoral fin. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55281 (12 images)
- cb761 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder with macrocephaly, seizures, and speech delay | 618158 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000095 | CRIB domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR033923 | p21 activated kinase binding domain |
| Family | IPR050285 | STE20 Serine/Threonine-Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036936 | CRIB domain superfamily |
Domain Details Per Protein
| Protein | Length | CRIB domain | CRIB domain superfamily | p21 activated kinase binding domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | STE20 Serine/Threonine-Protein Kinase |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P9X9
|
587 | ||||||||
|
UniProtKB:Q803Z0
|
577 | ||||||||
|
UniProtKB:A0A8M9PFA6
|
579 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available