ZFIN ID: ZDB-GENE-021011-2
Gene Name: p21 protein (Cdc42/Rac)-activated kinase 2a
Gene Symbol: pak2a    Nomenclature History

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Previous Names: pak2 (1), cb422 (1), redhead (1), rhd (1), si:dz198m22.1, wu:fb71h01, zgc:91798

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in blood vessel development. Predicted to localize to cytoplasm. Is expressed in several structures, including Kupffer's vesicle; axial mesoderm; axial vasculature; axis; and central nervous system. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2).
Genome Resources: Alliance (1),  Gene:266749 (1),  Ensembl(GRCz11):ENSDARG00000068177 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mi149 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39879 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pak2a N/A 2
    MO2-pak2a N/A 1
    MO3-pak2a N/A 1
    MO4-pak2a N/A 1
    MO5-pak2a N/A 1
    PHENOTYPE
    Data: 4 figures from 3 publications
    Observed in:
    DISEASE ASSOCIATED WITH pak2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pak2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel development (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pak2a-001 (1) 2651
    pak2a-203 (1)    Ensembl 2569
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-pak Rabbit IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pak2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(nkx2.3:pak2a) nkx2.3 pak2a Danio rerio 1 2
    Tg(nkx2.3:pak2a-CAAX,myl7:EGFP) myl7nkx2.3 CAAXEGFPpak2a Danio rerio 1 1
    Tg(UAS:pak2a_K299R,cryaa:Cerulean) cryaaUAS Ceruleanpak2a Danio rerio 1 2
    MARKER RELATIONSHIPS
    pak2a Contained in: [BAC] CH211-96I7 (1)
    [PAC] BUSM1-198M22 (1)
    pak2a Encodes: [EST] cb422 (1) (order this), fb71h01
    [cDNA] MGC:91798, MGC:193113 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002717 (1) 2707 nt
    Genomic GenBank:BX901889 (1) 172284 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IRH8 (1) 518 aa
    Sequence Information (all 27)
    ORTHOLOGY for pak2a ( Chr: 2 )
    CITATIONS (44)