Gene
pak2a
- ID
- ZDB-GENE-021011-2
- Name
- p21 protein (Cdc42/Rac)-activated kinase 2a
- Symbol
- pak2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in blood vessel development. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Is expressed in several structures, including Kupffer's vesicle; axial mesoderm; axial vasculature; axis; and central nervous system. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91798 (8 images)
- cb422 (22 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Knobloch syndrome 2 | 618458 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000095 | CRIB domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR033923 | p21 activated kinase binding domain |
| Domain | IPR035064 | p21-activated kinase 2, catalytic domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036936 | CRIB domain superfamily |
Domain Details Per Protein
| Protein | Length | CRIB domain | CRIB domain superfamily | p21-activated kinase 2, catalytic domain | p21 activated kinase binding domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DG42
|
517 |
Interactions and Pathways
No data available
Plasmids
No data available