Gene
pak2a
- ID
- ZDB-GENE-021011-2
- Name
- p21 protein (Cdc42/Rac)-activated kinase 2a
- Symbol
- pak2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in blood vessel development. Predicted to localize to cytoplasm. Is expressed in several structures, including Kupffer's vesicle; axial mesoderm; axial vasculature; axis; and central nervous system. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 18 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91798 (8 images)
- cb422 (22 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
?Knobloch syndrome 2 | 618458 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000095 | CRIB domain |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR033923 | p21 activated kinase binding domain |
Domain | IPR035064 | p21-activated kinase 2, catalytic domain |
Family | IPR050285 | STE20 Serine/Threonine-Protein Kinase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR036936 | CRIB domain superfamily |
Domain Details Per Protein
Protein | Length | CRIB domain | CRIB domain superfamily | p21-activated kinase 2, catalytic domain | p21 activated kinase binding domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | STE20 Serine/Threonine-Protein Kinase |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6DG42
|
517 |
Interactions and Pathways
No data available
Plasmids
No data available