Gene
pak2b
- ID
- ZDB-GENE-030131-3759
- Name
- p21 protein (Cdc42/Rac)-activated kinase 2b
- Symbol
- pak2b Nomenclature History
- Previous Names
-
- wu:fc52b03
- zgc:113857
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development. Predicted to be active in cytoplasm. Is expressed in axial vasculature; endoderm; and nervous system. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898349 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Knobloch syndrome 2 | 618458 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CRIB domain | CRIB domain superfamily | p21-activated kinase 2, catalytic domain | p21 activated kinase binding domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | STE20 Serine/Threonine-Protein Kinase |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BI44
|
520 | |||||||||
|
UniProtKB:Q4V9B9
|
539 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-159L23 | ZFIN Curated Data | |
| Encodes | EST | fc52b03 | ||
| Encodes | EST | IMAGE:6898349 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:113857 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025456 (1) | 2786 nt | ||
| Genomic | GenBank:CT027565 (1) | 79954 nt | ||
| Polypeptide | UniProtKB:Q4V9B9 (1) | 539 aa |
- Peng, X., Lai, K.S., She, P., Kang, J., Wang, T., Li, G., Zhou, Y., Sun, J., Jin, D., Xu, X., Liao, L., Liu, J., Lee, E., Poss, K.D., Zhong, T.P. (2020) Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Journal of molecular cell biology. 13(1):41-58
- Kamstra, J.H., Hurem, S., Martin, L.M., Lindeman, L.C., Legler, J., Oughton, D., Salbu, B., Brede, D.A., Lyche, J.L., Aleström, P. (2018) Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish. Scientific Reports. 8:15373
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kovács, R., Csenki, Z., Bakos, K., Urbányi, B., Horváth, Á., Garaj-Vrhovac, V., Gajski, G., Gerić, M., Negreira, N., López de Alda, M., Barceló, D., Heath, E., Kosjek, T., Žegura, B., Novak, M., Zajc, I., Baebler, Š., Rotter, A., Ramšak, Ž., Filipič, M. (2015) Assessment of toxicity and genotoxicity of low doses of 5-fluorouracil in zebrafish (Danio rerio) two-generation study. Water research. 77:201-212
- Kelly, M.L., Astsaturov, A., Rhodes, J., Chernoff, J. (2014) A Pak1/Erk Signaling Module Acts through Gata6 to Regulate Cardiovascular Development in Zebrafish. Developmental Cell. 29:350-9
- Law, S.H., and Sargent, T.D. (2013) Maternal pak4 Expression is Required for Primitive Myelopoiesis in Zebrafish. Mechanisms of Development. 130(2-3):181-194
- Tay, H.G., Ng, Y.W., and Manser, E. (2010) A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. PLoS One. 5(4):e10125
- Buchner, D.A., Su, F., Yamaoka, J.S., Kamei, M., Shavit, J.A., Barthel, L.K., McGee, B., Amigo, J.D., Kim, S., Hanosh, A.W., Jagadeeswaran, P., Goldman, D., Lawson, N.D., Raymond, P.A., Weinstein, B.M., Ginsburg, D., and Lyons, S.E. (2007) pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(35):13996-140001
- Liu, J., Fraser, S.D., Faloon, P.W., Rollins, E.L., Vom Berg, J., Starovic-Subota, O., Laliberte, A.L., Chen, J.N., Serluca, F.C., and Childs, S.J. (2007) A βPix–Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(35):13990-13995
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