ZFIN Gene: egr2a

ZFIN ID: ZDB-GENE-030723-6

ZFIN ID: ZDB-GENE-030723-6

Gene Name:

early growth response 2a

Gene Symbol:

egr2a Nomenclature History

Previous Names:

frb35 (1), krox20

Gene Type:

protein_coding_gene

Location:

Chr: 17 Mapping Details/Browsers

Description:

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in hindbrain and hindbrain neural keel. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2).

Genome Resources:

Alliance (1), Gene:368241 (1), Ensembl(GRCz11):ENSDARG00000044098 (2)

GENE EXPRESSION
All Expression Data:	9 figures from 6 publications
Wild-type Stages, Structures:	Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
	facial nerve motor nucleus hindbrain presumptive rhombomere 3 presumptive rhombomere 5 rhombomere 3 rhombomere 5 trigeminal motor nucleus unspecified vagal lobe whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa32172	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-egr2a		2
CRISPR2-egr2a		2
CRISPR3-egr2a		2
CRISPR4-egr2a		2
CRISPR5-egr2a		2
CRISPR6-egr2a		2
CRISPR7-egr2a		2
CRISPR8-egr2a		2
CRISPR9-egr2a		2
MO1-egr2a	N/A	1

PHENOTYPE No data available

DISEASE ASSOCIATED WITH egr2a HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 1D	Alliance	Charcot-Marie-Tooth disease, type 1D	607678
Charcot-Marie-Tooth disease type 3	Alliance	Dejerine-Sottas disease	145900
Charcot-Marie-Tooth disease type 4E	Alliance	Hypomyelinating neuropathy, congenital, 1	605253

DISEASE ASSOCIATED WITH egr2a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	regulation of transcription by RNA polymerase II (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 7)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	egr2a-201 (1)	1361	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	egr2a-202 (1)	1863	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	egr2a-203 (1)	1367	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM egr2a No data available

MARKER RELATIONSHIPS

egr2a Contained in:	[BAC] DKEY-84K15 (1) (order this)
egr2a Encodes:	[cDNA] MGC:195306 (1), MGC:195311 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_183341 (1)	1877 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX927349 (1)	159649 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7F266 (1)	393 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 25)

ORTHOLOGY for egr2a ( Chr: 17 )

CITATIONS (39)

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