ZFIN ID: ZDB-GENE-030723-6
Gene Name: early growth response 2a
Gene Symbol: egr2a    Nomenclature History

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Previous Names: frb35 (1), krox20

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in hindbrain and hindbrain neural keel. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2).
Genome Resources: Alliance (1),  Gene:368241 (1),  Ensembl(GRCz11):ENSDARG00000044098 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32172 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-egr2a
    2
    CRISPR2-egr2a
    2
    CRISPR3-egr2a
    2
    CRISPR4-egr2a
    2
    CRISPR5-egr2a
    2
    CRISPR6-egr2a
    2
    CRISPR7-egr2a
    2
    CRISPR8-egr2a
    2
    CRISPR9-egr2a
    2
    MO1-egr2a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH egr2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 1D Alliance Charcot-Marie-Tooth disease, type 1D 607678
    Charcot-Marie-Tooth disease type 3 Alliance Dejerine-Sottas disease 145900
    Charcot-Marie-Tooth disease type 4E Alliance Hypomyelinating neuropathy, congenital, 1 605253
    DISEASE ASSOCIATED WITH egr2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription by RNA polymerase II (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA egr2a-201 (1)    Ensembl 1361
    egr2a-202 (1)    Ensembl 1863
    egr2a-203 (1)    Ensembl 1367
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM egr2a No data available
    MARKER RELATIONSHIPS
    egr2a Contained in: [BAC] DKEY-84K15 (1) (order this)
    egr2a Encodes: [cDNA] MGC:195306 (1), MGC:195311 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_183341 (1) 1877 nt
    Genomic GenBank:BX927349 (1) 159649 nt
    Select Tool
    Polypeptide UniProtKB:E7F266 (1) 393 aa
    Sequence Information (all 25)
    ORTHOLOGY for egr2a ( Chr: 17 )
    CITATIONS (39)