PUBLICATION

A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish

Authors
Sun, Z., Shi, K., Su, Y., and Meng, A.
ID
ZDB-PUB-020514-4
Date
2002
Source
Mechanisms of Development   114(1-2): 133 (Journal)
Registered Authors
Meng, Anming, Su, Ying
Keywords
zebrafish; krox-20; krx-20; frb35; hindbrain; rhombomeres
MeSH Terms
  • Animals
  • Sequence Homology, Amino Acid
  • Transcription Factors/biosynthesis*
  • Transcription Factors/chemistry*
  • Transcription Factors/genetics
  • Zebrafish Proteins/biosynthesis*
  • Zebrafish Proteins/chemistry*
  • Zebrafish Proteins/genetics
  • Early Growth Response Protein 2
  • DNA, Complementary/metabolism
  • Molecular Sequence Data
  • Zebrafish
  • Protein Structure, Tertiary
  • Amino Acid Sequence
  • DNA-Binding Proteins/biosynthesis*
  • DNA-Binding Proteins/chemistry*
  • Time Factors
  • Zinc Fingers*
(all 18)
PubMed
12175499 Full text @ Mech. Dev.
Abstract
Krx-20, a zinc finger protein, plays an essential role in hindbrain segmentation of vertebrates. Zebrafish gene frb35 encodes a novel zinc finger protein that shares a high homology with Krx-20. The expression domains of frb35 overlap those of krx-20. The expression of frb35 first occurs in the 3rd rhombomere primordium at the onset of segmentation, which is soon followed by expression in the 5th rhombomere. From mid- segmentation onward, the 5th rhombomere has a higher frb35 expression level than the 3rd rhombomere. Unlike krx20, frb35 expression persists in the 5th rhombomere until the end of pharyngula period.
Genes / Markers
Figures
Figure Gallery (1 images)
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Sun, Z., Shi, K., Su, Y., and Meng, A. (2002) A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish. Mechanisms of Development. 114(1-2):133.