PUBLICATION
A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish
- Authors
- Sun, Z., Shi, K., Su, Y., and Meng, A.
- ID
- ZDB-PUB-020514-4
- Date
- 2002
- Source
- Mechanisms of Development 114(1-2): 133 (Journal)
- Registered Authors
- Meng, Anming, Su, Ying
- Keywords
- zebrafish; krox-20; krx-20; frb35; hindbrain; rhombomeres
- MeSH Terms
-
- Zebrafish
- Protein Structure, Tertiary
- Transcription Factors/biosynthesis*
- Transcription Factors/chemistry*
- Transcription Factors/genetics
- Sequence Homology, Amino Acid
- Amino Acid Sequence
- Molecular Sequence Data
- Zinc Fingers*
- DNA, Complementary/metabolism
- DNA-Binding Proteins/biosynthesis*
- DNA-Binding Proteins/chemistry*
- Animals
- Time Factors
- Early Growth Response Protein 2
- Zebrafish Proteins/biosynthesis*
- Zebrafish Proteins/chemistry*
- Zebrafish Proteins/genetics
- PubMed
- 12175499 Full text @ Mech. Dev.
Citation
Sun, Z., Shi, K., Su, Y., and Meng, A. (2002) A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish. Mechanisms of Development. 114(1-2):133.
Abstract
Krx-20, a zinc finger protein, plays an essential role in hindbrain segmentation of vertebrates. Zebrafish gene frb35 encodes a novel zinc finger protein that shares a high homology with Krx-20. The expression domains of frb35 overlap those of krx-20. The expression of frb35 first occurs in the 3rd rhombomere primordium at the onset of segmentation, which is soon followed by expression in the 5th rhombomere. From mid- segmentation onward, the 5th rhombomere has a higher frb35 expression level than the 3rd rhombomere. Unlike krx20, frb35 expression persists in the 5th rhombomere until the end of pharyngula period.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping