ZFIN is now using GRCz12tu for Genomic Data
Gene
glula
- ID
- ZDB-GENE-030131-688
- Name
- glutamate-ammonia ligase (glutamine synthase) a
- Symbol
- glula Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable glutamine synthetase activity. Predicted to be involved in glutamine biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic system; musculature system; and nervous system. Human ortholog(s) of this gene implicated in congenital glutamine deficiency; epilepsy (multiple); heart disease; and neurodegenerative disease (multiple). Orthologous to human GLUL (glutamate-ammonia ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 60 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb195 (14 images)
- cb757 (34 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhao et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital glutamine deficiency | Alliance | Glutamine deficiency, congenital | 610015 |
| developmental and epileptic encephalopathy 116 | Alliance | Developmental and epileptic encephalopathy 116 | 620806 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR027302 | Glutamine synthetase, N-terminal conserved site |
| Conserved_site | IPR027303 | Glutamine synthetase, glycine-rich site |
| Domain | IPR008146 | Glutamine synthetase, catalytic domain |
| Domain | IPR008147 | Glutamine synthetase, N-terminal domain |
| Family | IPR050292 | Glutamine Synthetase |
| Homologous_superfamily | IPR014746 | Glutamine synthetase/guanido kinase, catalytic domain |
| Homologous_superfamily | IPR036651 | Glutamine synthetase, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutamine Synthetase | Glutamine synthetase, catalytic domain | Glutamine synthetase, glycine-rich site | Glutamine synthetase/guanido kinase, catalytic domain | Glutamine synthetase, N-terminal conserved site | Glutamine synthetase, N-terminal domain | Glutamine synthetase, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T2P7 | InterPro | 371 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers