Gene

cars2

ID

ZDB-GENE-030131-5564

Name

cysteinyl-tRNA synthetase 2, mitochondrial

Symbol

cars2 Nomenclature History

Previous Names

fi04c12
si:ch211-198k9.5
wu:fi04c12 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Acts upstream of or within gonadotrophin-releasing hormone neuronal migration to the hypothalamus. Predicted to be active in cytoplasm. Is expressed in cerebellum and epiphysis. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 27. Orthologous to human CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Liu et al., 2021

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Wang et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 27	Alliance	Combined oxidative phosphorylation deficiency 27	616672

Associated With cars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR032678	tRNA synthetases class I, catalytic domain
Family	IPR015803	Cysteine-tRNA ligase
Family	IPR024909	Cysteinyl-tRNA synthetase/mycothiol ligase
Homologous_superfamily	IPR009080	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold

Domain Details Per Protein

Protein	Length	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding	Cysteine-tRNA ligase	Cysteinyl-tRNA synthetase/mycothiol ligase	Rossmann-like alpha/beta/alpha sandwich fold	tRNA synthetases class I, catalytic domain
UniProtKB:E7FC09 InterPro	566

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cars2-201 (1) Ensembl	Ensembl		2,236 nt	Select Tool ZFIN BLAST
ncRNA	cars2-002 (1) Ensembl	Ensembl		798 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations