Gene

tgif1

ID

ZDB-GENE-030131-475

Name

TGFB-induced factor homeobox 1

Symbol

tgif1 Nomenclature History

Previous Names

fa06h05
fb33g11
wu:fa06h05
wu:fb33g11
zgc:55852

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nervous system development; regulation of signal transduction; and sensory epithelium regeneration. Predicted to be located in nucleus. Is expressed in several structures, including forebrain neural plate; neural tube; presumptive diencephalon; retinal neural layer; and spinal cord neural keel. Used to study holoprosencephaly. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to human TGIF1 (TGFB induced factor homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55852 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tgif1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
holoprosencephaly 4	Alliance	Holoprosencephaly 4	142946

Associated With tgif1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
holoprosencephaly	WT + MO1-tgif1	standard conditions	Gongal et al., 2008

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001356	Homeodomain
Domain	IPR008422	KN homeodomain
Family	IPR050224	Three Amino acid Loop Extension (TALE) homeobox
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Length	Homedomain-like superfamily	Homeodomain	KN homeodomain	Three Amino acid Loop Extension (TALE) homeobox
UniProtKB:Q803F0 InterPro	273

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tgif1-201 (1) Ensembl	Ensembl	2,302 nt	Select Tool ZFIN BLAST
mRNA	tgif1-202 (1) Ensembl	Ensembl	730 nt	Select Tool ZFIN BLAST
mRNA	tgif1-203 (1) Ensembl	Ensembl	3,067 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tgif1	polyclonal	tgif1	IgG	Rabbit	IHC WB	Santa Cruz Biotechnology, Inc.	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations