Zebrafish E-cadherin: Expression during early embryogenesis and regulation during brain development
- Babb, S.G., Barnett, J., Doedens, A.L., Cobb, N., Liu, Q., Sorkin, B.C., Yelick, P.C., Raymond, P.A., and Marrs, J.A.
- Developmental dynamics : an official publication of the American Association of Anatomists 221(2): 231-237 (Journal)
- Registered Authors
- Clendenon, Sherry, Liu, Qin, Marrs, James A., Raymond, Pamela, Yelick, Pamela C.
- cadherin; zebrafish; Danio rerio; neurogenesis; midbrain; hindbrain; wnt1; pax2.1; cyclops
- MeSH Terms
- Blotting, Northern
- DNA, Complementary/metabolism
- DNA-Binding Proteins/biosynthesis
- Embryo, Nonmammalian/metabolism*
- Fungal Proteins/biosynthesis
- Gene Expression Regulation*
- Gene Library
- In Situ Hybridization
- Nervous System/embryology
- Nicotinamide-Nucleotide Adenylyltransferase
- PAX2 Transcription Factor
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Analysis, DNA
- Signal Transduction
- Time Factors
- Tissue Distribution
- Transcription Factors/biosynthesis
- Zebrafish Proteins
- 11376490 Full text @ Dev. Dyn.
Babb, S.G., Barnett, J., Doedens, A.L., Cobb, N., Liu, Q., Sorkin, B.C., Yelick, P.C., Raymond, P.A., and Marrs, J.A. (2001) Zebrafish E-cadherin: Expression during early embryogenesis and regulation during brain development. Developmental dynamics : an official publication of the American Association of Anatomists. 221(2):231-237.
Zebrafish E-cadherin (cdh1) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis. Expression was observed in blastomeres, the anterior mesoderm during gastrulation, and developing epithelial structures. In the developing nervous system, cdh1 was detected at the pharyngula stage (24 hpf) in the midbrain-hindbrain boundary (MHB). Developmental regulation of MHB formation involves wnt1 and pax2.1. wnt1 expression preceded cdh1 expression during MHB formation, and cdh1 expression in the MHB was dependent on normal development of this structure.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes