PUBLICATION

Zebrafish E-cadherin: Expression during early embryogenesis and regulation during brain development

Authors
Babb, S.G., Barnett, J., Doedens, A.L., Cobb, N., Liu, Q., Sorkin, B.C., Yelick, P.C., Raymond, P.A., and Marrs, J.A.
ID
ZDB-PUB-010601-7
Date
2001
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   221(2): 231-237 (Journal)
Registered Authors
Clendenon, Sherry, Liu, Qin, Marrs, James A., Raymond, Pamela, Yelick, Pamela C.
Keywords
cadherin; zebrafish; Danio rerio; neurogenesis; midbrain; hindbrain; wnt1; pax2.1; cyclops
MeSH Terms
  • Gene Expression Regulation*
  • DNA, Complementary/metabolism
  • Zebrafish
  • Sequence Analysis, DNA
  • Gene Library
  • Zebrafish Proteins
  • Brain/embryology*
  • Nervous System/embryology
  • Time Factors
  • In Situ Hybridization
  • Nicotinamide-Nucleotide Adenylyltransferase
  • Reverse Transcriptase Polymerase Chain Reaction
  • Animals
  • Tissue Distribution
  • Blotting, Northern
  • Transcription Factors/biosynthesis
  • Nucleotidyltransferases/genetics
  • Nucleotidyltransferases/metabolism*
  • DNA-Binding Proteins/biosynthesis
  • Fungal Proteins/biosynthesis
  • Embryo, Nonmammalian/metabolism*
  • Signal Transduction
  • Cadherins/biosynthesis*
  • PAX2 Transcription Factor
PubMed
11376490 Full text @ Dev. Dyn.
Abstract
Zebrafish E-cadherin (cdh1) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis. Expression was observed in blastomeres, the anterior mesoderm during gastrulation, and developing epithelial structures. In the developing nervous system, cdh1 was detected at the pharyngula stage (24 hpf) in the midbrain-hindbrain boundary (MHB). Developmental regulation of MHB formation involves wnt1 and pax2.1. wnt1 expression preceded cdh1 expression during MHB formation, and cdh1 expression in the MHB was dependent on normal development of this structure.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping