Gene
ctsd
- ID
- ZDB-GENE-010131-8
- Name
- cathepsin D
- Symbol
- ctsd Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have aspartic-type endopeptidase activity. Involved in muscle structure development; response to bacterium; and retinal pigment epithelium development. Predicted to localize to lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Is expressed in several structures, including eye; liver; muscle; pleuroperitoneal region; and unfertilized egg. Orthologous to human CTSD (cathepsin D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55226 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neuronal ceroid lipofuscinosis 10 | Alliance | Ceroid lipofuscinosis, neuronal, 10 | 610127 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001969 | Aspartic peptidase, active site |
| Domain | IPR012848 | Aspartic peptidase, N-terminal |
| Domain | IPR033121 | Peptidase family A1 domain |
| Family | IPR001461 | Aspartic peptidase A1 |
| Family | IPR033144 | Cathepsin D |
| Homologous_superfamily | IPR021109 | Aspartic peptidase domain superfamily |
Domain Details Per Protein
| Protein | Length | Aspartic peptidase A1 | Aspartic peptidase, active site | Aspartic peptidase domain superfamily | Aspartic peptidase, N-terminal | Cathepsin D | Peptidase family A1 domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8AWD9
|
398 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-ctsd | monoclonal | IgG2a | Mouse |
|
BD Biosciences
|
1 |
Plasmids
No data available