Gene
supt5h
- ID
- ZDB-GENE-001207-1
- Name
- SPT5 homolog, DSIF elongation factor subunit
- Symbol
- supt5h Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Exhibits DNA binding activity. Involved in several processes, including generation of neurons; regulation of signal transduction; and regulation of transcription elongation from RNA polymerase II promoter. Localizes to nucleus. Is expressed in brain and optic cup. Orthologous to human SUPT5H (SPT5 homolog, DSIF elongation factor subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66413 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005100 | NGN domain |
| Domain | IPR005824 | KOW |
| Domain | IPR006645 | NusG-like, N-terminal |
| Domain | IPR022581 | Spt5 transcription elongation factor, N-terminal |
| Domain | IPR024945 | Spt5 C-terminal domain |
| Domain | IPR039385 | NGN domain, eukaryotic |
| Domain | IPR041973 | Spt5, KOW domain repeat 1 |
| Domain | IPR041975 | Spt5, KOW domain repeat 2 |
| Domain | IPR041976 | Spt5, KOW domain repeat 3 |
| Domain | IPR041977 | Spt5, KOW domain repeat 4 |
| Domain | IPR041978 | Spt5, KOW domain repeat 5 |
| Domain | IPR041980 | Spt5, KOW domain repeat 6 |
| Family | IPR017071 | Transcription elongation factor Spt5, eukaryote |
| Family | IPR039659 | Transcription elongation factor SPT5 |
| Homologous_superfamily | IPR008991 | Translation protein SH3-like domain superfamily |
| Homologous_superfamily | IPR014722 | Large ribosomal subunit protein uL2, domain 2 |
| Homologous_superfamily | IPR036735 | NusG, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | KOW | Large ribosomal subunit protein uL2, domain 2 | NGN domain | NGN domain, eukaryotic | NusG-like, N-terminal | NusG, N-terminal domain superfamily | Spt5 C-terminal domain | Spt5, KOW domain repeat 1 | Spt5, KOW domain repeat 2 | Spt5, KOW domain repeat 3 | Spt5, KOW domain repeat 4 | Spt5, KOW domain repeat 5 | Spt5, KOW domain repeat 6 | Spt5 transcription elongation factor, N-terminal | Transcription elongation factor SPT5 | Transcription elongation factor Spt5, eukaryote | Translation protein SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9DDT5
|
1084 | |||||||||||||||||
|
UniProtKB:A0A8M9Q0J3
|
1086 | |||||||||||||||||
|
UniProtKB:A0A8M1P6F8
|
1084 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
supt5h-201
(1)
|
Ensembl | 3,868 nt | ||
| mRNA |
supt5h-202
(1)
|
Ensembl | 4,024 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-supt5h | polyclonal | Rabbit |
|
1 |
Plasmids
No data available